Piercing needle

• US 6,656,167 B2
• Filed: 01/08/2001
• Issued: 12/02/2003
• Est. Priority Date: 01/07/2000
• Status: Active Grant

• Current Assignee: Nipro Corporation
• Original Assignee: Nipro Corporation
• Inventors: Wada, Nobuo, Nizuka, Takeshi, Ishida, Masashi, Numao, Taku
• Primary Examiner(s): MILLER, CARL STUART
• Application Number:
  US09/755,039
• Publication Number:
  US 20010021832A1
• Time in Patent Office: 1,058 Days
• Field of Search: 604/272, 604/265, 604/266, 295/272, 427/387, 427/388, 427/2, 427/409, 427/435, 427/452, 427/2.12, 427/2.28, 427/2.3
• US Class Current: 604/272
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61M 5/3286 Needle tip design, e.g. for improved penetration
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A piercing needle having a low piercing resistance even if repeatedly caused to pierce is provided. The piercing needle has an undercoat of a silane coupling agent, preferably, an amino group-containing alkoxysilane or an epoxy group-containing alkoxysilane, and an outer surface of a mixture of a (1) reactive silicone such as a reaction product of an amino group-containing alkoxysilane, an epoxy group-containing alkoxysilane and a silicone having silanol groups at both terminal ends, with (2) a non-reactive silicone.

Claims

1. A piercing needle comprising a needle having an undercoat of a silane coupling agent and an outer surface of a mixture of a reactive silicone and a non-reactive silicone, wherein said reactive silicone is a compound containing an alkoxy group in a terminal end and comprising a nitrogen atom in the molecular chain.

2. A piercing needle according to claim 1, wherein said silane coupling agent is one or more compounds selected from the group consisting of a halogen-containing silane, an amino group-containing silane, an epoxy-group containing silane, a mercapto group-containing silane, an isocyanate group-containing silane, an azide group-containing silane, a polysulfide group-containing silane, an alkenyl group-containing silane and an alkoxy group-containing silane, or a reaction product thereof.

3. A piercing needle according to claim 1, wherein said silane coupling agent is one or more compounds selected from the group consisting of an amino group-containing alkoxysilane and an epoxy group-containing alkoxysilane, or a reaction product thereof.

4. A piercing needle according to claim 1, wherein said silane coupling agent is an amino group-containing alkoxysilane selected from the group consisting of N-β

(aminoethyl) Υ

aminopropylmethyldimethoxysilane, N-β

(aminoethyl) Υ

-aminopropyltrimethoxysilane, N-β

(aminoethyl)Υ

-aminopropyltriethoxysilane, Υ

-aminopropyltrimethoxysilane, Υ

-aminopropylmethyldiethoxysilane, and Υ

-aminopropyltriethoxysilane.

5. A piercing needle according to claim 1, wherein said silane coupling agent is an epoxy-containing alkoxysilane selected from the group consisting of Υ

-glycidoxypropyltrimethoxysilane, Υ

-glycidoxypropylmethyldiethoxysilane, Υ

-glycidoxypropyltriethoxysilane and β

-(3,4-epoxycyclohexyl) ethyltrimethoxysilane.

6. A piercing needle according to claim 1, wherein said reactive silicone is a compound obtained by the reaction of (a) an amino group-containing alkoxysilane, (b) an epoxy group-containing alkoxysilane and (c) a silicone having silanol groups in both terminal ends thereof.

7. A piercing needle according to claim 1, wherein said reactive silicone is a reaction product of (a′

) a polyorganosiloxane having silanol groups at both terminal ends with (b′

) a reaction product of an organosilane having an amino group at a terminal end with an epoxy group-containing alkoxysilane.

8. A piercing needle according to claim 1, wherein said reactive silicone is a reaction product of (a″

) a polyorganosiloxane having amino groups at both terminal ends and having alkoxysilyl groups with (b″

) an epoxy group-containing alkoxysilane.

9. A piercing needle according to claim 1, wherein said reactive silicone is a compound obtained by the following steps (1) and (2)

(1):

reacting a silicone having silanol groups at both terminal ends thereof with an amino group-containing alkoxysilane; and

(2);

reacting the compound obtained in step (1) with an epoxy group-containing alkoxysilane.

10. A piercing needle according to claim 1, wherein said reactive silicone is a compound obtained by the following steps (1) and (2):

(1);

reacting an epoxy group-containing alkoxysilane with an amino group-containing alkoxysilane; and

(2);

reacting the compound obtained in the step (1) with a silicone having silanol groups at both terminal ends thereof.

11. A piercing needle according to claim 1, wherein said non-reactive silicone is one or more compounds selected from the group consisting of dimethylsilicone, methylphenylsilicone, alkyl modified silicone, fluorosilicone, polyether modified silicone and fatty acid ester modified silicone.

12. A piercing needle according to claim 1, wherein a mixing ratio of said mixture is 1 to 7 parts by weight of the non-reactive silicone based on 10 parts by weight of the reactive silicone.

13. A piercing needle according to claim 1, wherein an average polymerization degree of siloxane unit in said reactive silicone is 10 to 10,000, and an average polymerization degree of siloxane unit in said non-reactive silicone is no more than the average polymerization degree of the siloxane parts of the reactive silicone.