Methods and apparatus for conformably sealing prostheses within body lumens

• US 6,656,214 B1
• Filed: 01/16/1998
• Issued: 12/02/2003
• Est. Priority Date: 09/08/1995
• Status: Expired due to Term

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Inventors: Lenker, Jay A., Cox, Brian J., Will, Allan R., Fogarty, Thomas J., Freislinger, Kirsten
• Primary Examiner(s): Snow, Bruce
• Application Number:
  US09/008,686
• Time in Patent Office: 2,146 Days
• Field of Search: 623/1, 623/12, 623/1.13, 623/1.14, 623/1.21, 623/1.25, 623/1.44, 623/1.36, 623/1.45, 606/192, 606/194, 606/195
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/945 hardenable, e.g. stents formed in situ
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/077 having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
• CPC Class Codes: A61F 2002/30583 filled with hardenable fluid, e.g. curable in-situ
• CPC Class Codes: A61F 2002/8483 Barbs
• CPC Class Codes: A61F 2210/0085 hardenable in situ, e.g. epoxy resins
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0054 V-shaped

Abstract

A tubular prosthesis is implanted at a target location within a body lumen by transluminally placing and embedding an expansible prosthesis body within a sealing layer. The sealing layer occludes at least a circumferential band within an interface region between the prosthesis body and the inner wall of the body lumen, thus providing for blockage of body lumen flow past the prosthesis. The sealing layer may be introduced prior to or simultaneously with the prosthesis body. A tubular prosthesis may be implanted in blood vessels, particularly to protect aneurysms.

Claims

1. A tubular prosthesis for implanting in a body lumen and directing blood flow through the body lumen, wherein said tubular prosthesis is expanded in situ so that an exterior surface of the tubular prosthesis engages an inner wall of the body lumen over an interface region, and an inner surface of said tubular prosthesis provides a blood barrier, said tubular prosthesis comprising:

a tubular frame with an interior surface and an exterior surface;

a blood-impermeable liner disposed on said interior surface of said tubular frame for preventing blood flow from said inner surface of said tubular prosthesis to said exterior surface of said tubular prosthesis; and

a flowable sealing layer disposed on at least a portion of said exterior surface of said tubular frame, said sealing layer being expansible together with said tubular frame and capable of conforming to a varying space to form a liquid-resistant barrier configured to prevent blood flow between said blood-impermeable liner of said tubular prosthesis and the inner wall of the body lumen over said interface region,

wherein said sealing layer is comprised of a hydrophilic material.

3. The tubular prosthesis as in claim 1, wherein said tubular frame is at least partly malleable so that it can be radially expanded by application of an external expansion force.

4. The tubular prosthesis as in claim 1, wherein said sealing layer is disposed over at least a circumferential band of said exterior surface of said tubular frame.

5. The tubular prosthesis as in claim 1, wherein said sealing layer is disposed over substantially the entire exterior surface of said tubular frame.

2. The tubular prosthesis as in claim 15, wherein said tubular frame is at least partly resilient so that it can be released from radial constraint to assume a large diameter configuration.

6. A tubular prosthesis, comprising:

an annular body having a self-expanding frame and a liner, wherein said liner provides a fluid barrier between an interior surface and an exterior surface of said annular body; and

a flowable sealing layer formed over at least an annular portion of said exterior surface of said body, wherein said sealing layer conforms to a varying space in an interface region of a body lumen by expanding to a varying thickness upon implantation in the interface region thereby forming a liquid resistant barrier between said annular exterior surface portion of said body and the interface region such that fluid is directed only through a lumen of said tubular prosthesis, wherein said sealing layer is comprised of a hydrophilic material.

7. The tubular prosthesis as in claim 6, wherein said sealing layer is disposed over at least a circumferential band of said exterior surface of said body.

8. The tubular prosthesis as in claim 6, wherein said sealing layer is disposed over substantially the entire exterior surface of said body.