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Compositions for the delivery of polynucleotides to cells

  • US 6,656,734 B1
  • Filed: 06/30/1998
  • Issued: 12/02/2003
  • Est. Priority Date: 07/01/1997
  • Status: Expired due to Fees
First Claim
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1. A process for transferring a therapeutically active polynucleotide into a target cell in vitro, wherein said cell is brought into contact with a composition comprising a mixture of at least one therapeutically active polynucleotide and at least one aprotic polar compound selected from the group consisting of:

  • (a) formula I;

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    wherein R1 and R2 are identical or different alkyl radicals of 1 to 8 carbon atoms which are optionally substituted, with the proviso that when one of R1 or R2 is a radical of 1 or 2 carbon atoms, the other is a radical of at least 3 carbon atoms;

    wherein the volume of the aprotic polar compound represents from 5 to 50% of the total volume of the composition, and wherein the polynucleotide prior to being part of the mixture, is free of any compound which facilitates its introduction into a target cell.

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