Device for verifying the accuracy of a spectral analyzer

• US 6,657,717 B2
• Filed: 02/28/2002
• Issued: 12/02/2003
• Est. Priority Date: 08/31/1999
• Status: Expired due to Fees

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: CME Telemetrix, Inc.
• Inventors: Kaushal, Ashwani, Bednarz, Bronislaw, Kuta, John, Cadell, Theodore E., Drennan, Paul, Samsoondar, James, Pawluczyk, Romuald
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): Nguyen, Sang H.
• Application Number:
  US10/085,983
• Publication Number:
  US 20020118361A1
• Time in Patent Office: 642 Days
• Field of Search: 356/243.1, 356/243.2, 356/243.3, 356/243.4, 356/243.5, 356/243.6, 356/243.7, 356/243.8, 356/247, 356/248, 356/39, 356/40, 356/41, 356/42, 250/252.1, 128/633, 128/665
• US Class Current: 356/243.1
• CPC Class Codes: A61B 2560/0233 Optical standards
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 21/4785 Standardising light scatter apparatus; Standards therefor
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/926 Topical chemical, e.g. cosmetic or sunscreen
• CPC Class Codes: Y10S 977/954 Of radiant energy
• CPC Class Codes: Y10S 977/958 Of biomolecule property

Abstract

The present invention provides an artificial member (80, 210) which mimics the absorbance spectrum of a body part and includes the spectral components of blood analytes. The artificial member comprises a light scattering and reflecting material, and has a chamber portion comprising one or more chambers (90, 100, 220). The artificial member is configured to be reproducibly received in a measuring receptor which receptor is operatively connected to a non-invasive monitoring device.

Claims

1. An artificial member comprising:

a) a housing defining a first and a second end, the housing having a solid wall, the solid wall defining one, or more than one chamber, the solid wall made of a light-scattering and light-reflecting material, the housing configured in the shape of a body part, the light-scattering and light-reflecting material approximating the light-scattering and light-absorbing characteristics of the body part, wherein the first and the second end are sealed.

2. The artificial member according to claim 1 wherein the body part is selected from the group consisting of a finger, a lip, an earlobe, a pinch of skin, a web of a hand, and a web between toes.

3. The artificial member according to claim 1, wherein the solid wall of the housing defines one chamber.

4. The artificial member according to claim 1, wherein the solid wall of the housing defines two chambers.

5. The artificial member according to claim 1, wherein the one, or more than one chamber is filled with an O-cellulose material.

6. The artificial member according to claim 1, wherein the one or more than one chamber is filled with a gel material containing Amaranth, sodium benzoate and light scattering and reflective particles.

7. The artificial member according to claim 6 wherein the light scattering and reflective particles comprise Teflon®

-polytetrafluoroethylene (PTFE), Titanium Dioxide (TiO₂) Polystyrene nanospheres, or a combination thereof.

8. The artificial member according to claim 1 wherein the light-scattering and light-reflecting material is selected from the group consisting of Teflon®

Teflon®

-PTFE, Teflon®

-PTFE with 25% glass fibers, and Fluorosint™

.

9. The artificial member according to claim 1, further comprising a stabilizing member extending from the outer portion to reversibly urge the artificial member into contact with a measuring receptor.

10. A method for verifying the precision and accuracy of a non-invasive monitoring device comprising:

a) inserting an artificial member into a measuring receptor, the measuring receptor operatively connected to the non-invasive monitoring device, the artificial member comprising a housing defining a first and a second end, the housing having a solid wall, the solid wall defining one, or more than one chamber, the solid wall made of a light-scattering and light-reflecting material, the housing configured in the shape of a body part, the light-scattering and light-reflecting material approximating the light-scattering and light-absorbing characteristics of the body part, wherein the first and the second end are sealed;

b) measuring the absorbance spectrum of the artificial member; and

c) comparing the absorbance spectrum of the artificial member with an absorbance spectrum obtained from the body part, thereby verifying the precision and accuracy of the non-invasive monitoring device.

11. The method according to claim 10, wherein the body part is selected from the group consisting of a finger, a lip, an earlobe, a pinch of skin, a web of a hand, and a web between toes.

12. The method according to claim 10, wherein the solid wall of the housing defines one chamber.

13. The method according to claim 10, wherein the solid wall of the housing defines two chambers.

14. The method according to claim 10, wherein the one, or more than one chamber is filled with an O-cellulose material.

15. The method according to claim 10, wherein the one, or more than one chamber is filled with a gel material containing Amaranth, sodium benzoate and light scattering and reflective particles.

16. The method according to claim 15, wherein the reflective particles comprise Teflon®

-PTFE, Titanium Dioxide (TiO₂) Polystyrene nanospheres, or a combination thereof.

17. The method according to claim 10, wherein the light-scattering and light-reflecting material is selected from the group consisting of Teflon®

, Teflon®

-PTFE, Teflon®

-PTFE with 25% glass fibers, and Fluorosint™

.

18. The method according to claim 10, wherein the artificial member further comprises a stabilizing member extending from the outer portion to reversibly urge the artificial member into contact with the measuring receptor.

19. An artificial member comprising:

a) a housing having a wall defining one, or more than one chamber, the wall made of a light-scattering and light-reflecting material selected from the group consisting of Teflon®

, Teflon®

-PTFE, Teflon®

-PTFE with 25% glass fibers, and Fluorosint™

, the housing configured in the shape of a body part.

20. The artificial member of claim 19, wherein the body part is selected from the group consisting of a finger, a lip, an earlobe, a pinch of skin, a web of a hand, and a web between toes.

21. The artificial member of claim 19, wherein the one or more than one chamber is filled with air, water, O-cellulose material, or a gel material containing Amaranth, sodium benzoate and reflective particles, or a combination thereof, the reflective particles comprising Teflon®

-PTFE, Titanium Dioxide (TiO₂) or polystyrene nanospheres.

22. The artificial member of claim 19, wherein the wall of the housing is solid.

23. The artificial member of claim 19, wherein the wall of the housing defines two, or more than two chambers.

24. The artificial member of claim 19, wherein the wall of the housing defines two chambers.

25. The artificial member of claim 19, wherein the housing defines a first and a second end, wherein the first and the second end are sealed.

26. A method for verifying the precision and accuracy of a non-invasive monitoring device comprising:

a) inserting an artificial member into a measuring receptor, the measuring receptor operatively connected to the non-invasive monitoring device, the artificial member comprising a housing having a wall defining one, or more than one chamber, the wall made of a light-scattering and light-reflecting material selected from the group consisting of Teflon®

, Teflon®

-PTFE, Teflon®

-PTFE with 25% glass fibers, and Fluorosint™

, the housing configured in the shape of a body part;

b) measuring the absorbance spectrum of the artificial member; and

c) comparing the absorbance spectrum of the artificial member with an absorbance spectrum obtained from the body part, thereby verifying the precision and accuracy of the non-invasive monitoring device.

27. The method of claim 26, wherein the body part is selected from the group consisting of a finger, a lip, an earlobe, a pinch of skin, a web of a hand, and a web between toes.

28. The method of claim 26, wherein the one or more than one chamber is filled with air, water, O-cellulose material, or a gel material containing Amaranth, sodium benzoate and reflective particles, or a combination thereof, the reflective particles comprising Teflon®

-PTFE, Titanium Dioxide (TiO₂) or polystyrene nanospheres.