Technique to measure capillary related interstitial fluid using ultra-sonic methods and devices

• US 6,659,949 B1
• Filed: 08/28/2000
• Issued: 12/09/2003
• Est. Priority Date: 08/19/1997
• Status: Expired due to Fees

• Current Assignee: National Institutes of Health (NIH) (Government of the United States of America)
• Original Assignee: National Institutes of Health (NIH) (Government of the United States of America)
• Inventors: Lang, Philipp, Mendlein, John D.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US09/650,431
• Time in Patent Office: 1,198 Days
• Field of Search: 600/437, 600/438, 600/448, 600/449, 600/459
• US Class Current: 600/438
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/4236 characterised by adhesive patches
• CPC Class Codes: A61B 8/4422 related to hygiene or sterilisation
• CPC Class Codes: A61B 8/4472 Wireless probes

Abstract

The present invention provides for methods and devices for monitoring capillary related interstitial thickness. The invention also includes methods of measuring capillary related interstitial fluid, as well as cardiac, vascular, renal and hepatic function. Specific devices, particularly probes, are provided for such methods.

Claims

1. A method of detecting rapid changes in capillary related interstitial fluid volume in a human, comprising:

a) positioning a first ultrasound probe on a skin surface of a first anatomical region of said human in need of capillary related interstitial fluid volume detection during a clinically relevant fine period,

b) interrogating said first anatomical region with ultrasound pulses from said first ultrasound probe, and

c) detecting a first capillary related interstitial fluid volume between an inner surface of skin and either a bone or fat surface in said first anatomical region with ultrasound signals from said ultrasound pulses, wherein said first capillary related interstitial fluid volume is an indicator of capillary related interstitial fluid volume of said first anatomical region or is an indicator of systemic capillary related interstitial fluid volume.

2. The method of claim 1, further comprising the step of comparing said first capillary related interstitial fluid volume to a predetermined value for capillary related interstitial fluid layer volume.

3. The method of claim 2, wherein said anatomical region is selected from the group consisting of a tibial region, a humerus region, a chest region, an abdominal region, and a cranial region.

4. The method of claim 3, wherein said measuring is a quantitative measurement of capillary related interstitial fluid volume comprising determining a capillary related interstitial layer thickness or a capillary related interstitial layer volume.

5. The method of claim 4, wherein said measuring detects about a 1 millimeter or greater change in interstitial layer thickness.

6. The method of claim 5, wherein said measuring occurs during at least two predetermined monitoring times or measuring occurs continuously during said clinically relevant time period.

7. The method of claim 6, wherein said measuring occurs over more than a 20 minute time frame.

8. The method of claim 7, wherein said probe remains in approximately the same position during said measuring and said measurements occur no less than 1 per minute at regularly spaced intervals.

9. The method of claim 8, further comprising placing a plurality of probes at different anatomical regions and performing steps (a) through (c) for each anatomical region.

10. The method of claim 9, wherein said plurality of probes comprises a left tibial region probe, and a right tibial region probe, wherein said steps (a) through (c) are performed concurrently with said plurality of probes.

11. The method of claim 10, wherein said plurality of probes further comprises a humerus probe, cranial probe, chest probe, and an abdominal probe, and wherein said steps (a) through (c) are performed concurrently with said plurality of probes.