Stent for increasing blood flow to ischemic tissues and a method of using the same
First Claim
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1. A stent, comprising:
- a tubular body having an outer surface configured to contact the wall of a vessel and an inner surface;
a first coating supported by the inner surface and containing an angiogenic substance, the first coating configured to release the angiogenic substance in the vessel; and
a second coating supported by the outer surface and containing a therapeutic substance capable of inhibiting migration or proliferation of smooth muscle cells, the second coating configured to apply the therapeutic substance to the wall of the vessel, wherein the outer surface is free from the first coating containing the angiogenic substance and the inner surface is free from the second coating containing the therapeutic substance.
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Abstract
An implantable stent for a vessel includes a tubular body having an inner and outer surface. The inner and outer surfaces are coated with therapeutic substances. The therapeutic substance of the inner surface, such as an angiogenic substance, can be released downstream in the lumen. The therapeutic substance of the outer surface can be applied to the inner surface of the vessel.
343 Citations
28 Claims
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1. A stent, comprising:
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a tubular body having an outer surface configured to contact the wall of a vessel and an inner surface;
a first coating supported by the inner surface and containing an angiogenic substance, the first coating configured to release the angiogenic substance in the vessel; and
a second coating supported by the outer surface and containing a therapeutic substance capable of inhibiting migration or proliferation of smooth muscle cells, the second coating configured to apply the therapeutic substance to the wall of the vessel, wherein the outer surface is free from the first coating containing the angiogenic substance and the inner surface is free from the second coating containing the therapeutic substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A stent for implanting in a blood vessel comprising a tubular structure having an inner surface and an outer surface, comprising:
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a first therapeutic substance carried by the inner surface, the first therapeutic substance configured to be released downstream with the flow of blood; and
a second therapeutic substance, different from the first therapeutic substance, the second therapeutic substance carried by the outer surface and configured to be delivered to the blood vessel wall, wherein the first therapeutic substance facilitates therapeutic angiogenesis and the second therapeutic substance inhibits migration or proliferation of smooth muscle cells, wherein the outer surface is free from the first therapeutic substance and wherein the inner surface is free from the second therapeutic substance. - View Dependent Claims (26, 27, 28)
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Specification