Apparatus for polymer synthesis
First Claim
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1. A reactor system for synthesizing a plurality of polymer sequences on a substrate comprising:
- a flow cell;
a system for delivering reaction fluids containing selected monomers to the flow cell;
a substrate having a surface exposed to the reaction fluids in the flow cell;
an energy source to direct energy at selected locations of the substrate to activate the substrate to react with the selected monomers in the reaction fluids, whereby the plurality of polymers sequences are synthesized at known locations on the substrate.
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Abstract
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
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11 Claims
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1. A reactor system for synthesizing a plurality of polymer sequences on a substrate comprising:
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a flow cell;
a system for delivering reaction fluids containing selected monomers to the flow cell;
a substrate having a surface exposed to the reaction fluids in the flow cell;
an energy source to direct energy at selected locations of the substrate to activate the substrate to react with the selected monomers in the reaction fluids, whereby the plurality of polymers sequences are synthesized at known locations on the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification