Oromucosal cytokine compositions and uses thereof
First Claim
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1. A method for treating diseases that would benefit from TH1 stimulation, comprising stimulating the host defense mechanisms in a mammal having such a disease by oromucosally administering an effective amount of a TH1-stimulating cytokine selected from the group consisting of IL-12, IL-18, TNF-β
- and GM-CSF, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
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Abstract
Pharmaceutical compositions for oromucosal; contact to stimulate host defense mechanisms in a mammal, having an effective amount of Th1 or Th2 stimulating cytokine, and methods of treatment with such compositions are provided.
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Citations
66 Claims
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1. A method for treating diseases that would benefit from TH1 stimulation, comprising stimulating the host defense mechanisms in a mammal having such a disease by oromucosally administering an effective amount of a TH1-stimulating cytokine selected from the group consisting of IL-12, IL-18, TNF-β
- and GM-CSF, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for treating diseases that would benefit from TH1 stimulation, comprising stimulating the host defense mechanisms in a mammal having such a disease by oromucosally administering, in a single dose, an effective amount of a TH1-stimulating cytokine selected from the group consisting of IL-2, IL-12, IL-15, IL-18, TNF-β
- and GM-CSF, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
- View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for treating allergic disorders, asthma or atopic dermatitis, comprising stimulating the host defense mechanisms in a mammal having such a disease by oromucosally administering an effective amount of a TH1-stimulating cytokine selected from the group consisting of IL-2, IL-12, IL-15, IL-18, TNF-β
- and GM-CSF, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
- View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39)
- 40. A method for treating diseases that would benefit from TH1 stimulation, comprising stimulating the host defense mechanisms in a mammal having such a disease by oromucosally administering IL-2 or IL-15 in an effective amount that is great enough to generate a pathological response if administered parenterally, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
- 55. A method for treating diseases that would benefit from TH2 stimulation, comprising stimulating the host defense mechanisms in a patient having such a disease by oromucosally administering an effective amount of a TH2-stimulating cytokine selected from the group consisting of IL-4, IL-5 and IL-13, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
- 62. A method for treating diseases that would benefit from TH2 stimulation, comprising stimulating the host defense mechanism in a patient having such a disease by oromucosally administering IL-10 in an effective amount that is great enough to generate a pathological response if administered parenterally, wherein said oromucosal administration is accomplished in a manner that provides contact of the cytokine with the oromucosal cavity of the recipient for a period of time sufficient to obtain the desired stimulation.
Specification