Fresh, cryopreserved, or minimally cardiac valvular xenografts

• US 6,660,265 B1
• Filed: 10/16/2000
• Issued: 12/09/2003
• Est. Priority Date: 10/15/1999
• Status: Expired due to Fees

• Current Assignee: Brigham and Women's Hospital Incorporated
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Adams, David H., Chen, Raymond H.
• Primary Examiner(s): Tate, Christopher R.
• Assistant Examiner(s): WINSTON, RANDALL O
• Application Number:
  US09/688,492
• Time in Patent Office: 1,149 Days
• Field of Search: 424/93.7, 435/395, 435/1.1
• US Class Current: 424/93.7
• CPC Class Codes: A01N 1/021 Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/3625 Vascular tissue, e.g. heart valves
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

The invention relates to the preparation of porcine cardiac valve leaflets for implantation into patients.

Claims

1. A method of treating a patient comprising implanting into the patient a viable isolated porcine cardiac valve leaflet that has not been contacted with an exogenous fixative.