Anti-HCV nucleoside derivatives
First Claim
1. A method for the treatment of hepatitis C virus (HCV) infection comprising administering a therapeutically effective amount of a compound of formula I-a whereinR1 is hydrogen or phosphate and B is a 1-pyrimidinyl or 9-purinyl residue of formulae B1, B2 or B3and pharmaceutically acceptable salts thereof.
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Abstract
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known 2′-deoxy-2′-fluoro nucleoside derivatives as inhibitors of hepatitis C virus (HCV) RNA replication and pharmaceutical compositions of such compounds. The compounds of this invention have potential use as therapeutic agents for the treatment of HCV infections.
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Citations
3 Claims
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1. A method for the treatment of hepatitis C virus (HCV) infection comprising administering a therapeutically effective amount of a compound of formula I-a
wherein R1 is hydrogen or phosphate and B is a 1-pyrimidinyl or 9-purinyl residue of formulae B1, B2 or B3 and pharmaceutically acceptable salts thereof.
Specification