Iontophoresis, electroporation and combination patches for local drug delivery to body tissues
First Claim
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1. A patch-based device for enhancing the local delivery of a treatment agent into target tissues comprising:
- a patch base having a tissue facing surface and a reservoir facing surface;
an iontophoresis and electroporation electrode network comprising a plurality of electrodes arranged in a spaced parallel pattern on the tissue facing surface of the patch base; and
a treatment agent reservoir on the reservoir facing surface of the patch base in fluid communication with the tissue facing surface of the patch base and the electrode network.
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Abstract
Patch-based devices for enhancing the local delivery of drugs, pharmaceuticals, plasmids, genes and other agents into the tissues of the living body. The patch devices provide an electrical driving force that can increase the rate of migration of drugs and other therapeutic agents out of a polymer matrix into body tissues and cells using iontophoresis only, electroporation only, or combined inontophoresis and electroporation. The two procedures may be applied sequentially in any order without removing or repositioning the patch.
98 Citations
20 Claims
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1. A patch-based device for enhancing the local delivery of a treatment agent into target tissues comprising:
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a patch base having a tissue facing surface and a reservoir facing surface;
an iontophoresis and electroporation electrode network comprising a plurality of electrodes arranged in a spaced parallel pattern on the tissue facing surface of the patch base; and
a treatment agent reservoir on the reservoir facing surface of the patch base in fluid communication with the tissue facing surface of the patch base and the electrode network. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
applying a treatment agent to the reservoir of the patch-based device of claim 1;
placing the patch on the target tissues to be treated; and
applying means for driving the treatment agent from the electrode network into the tissue walls.
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15. The method of claim 14, wherein the means for driving the treatment agent from the electrode network into the target tissues comprise iontophoretic means.
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16. The method of claim 15, further comprising electroporation means to further drive the treatment agent from the electrode network into the target tissues.
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17. The method of claim 14, wherein the means for driving the treatment agent from the electrode network into the target tissues comprise electroporation means.
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18. The method of claim 14, wherein the treatment agent is placed in a reservoir and the patch is implanted on the target tissue, and wherein the device further comprises a recharging tube connected to the reservoir such that treatment agent may be delivered through the tube, into the reservoir and from the reservoir through the patch base and into the target tissues.
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19. The method of claim 14, wherein the treatment agent is encapsulated within biodegradable microparticles or liposomes that are placed in an area between the target tissue and the patch such that the treatment agent can be made available for electrically enhanced delivery by electroporation of the microparticles or liposomes.
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20. The method of claim 14, wherein the treatment agent is encapsulated within ultrasonically labile microspheres;
- and the later step of applying ultrasonic energy to fragment the microspheres to release the treatment agent which then passes from the reservoir to the target tissue where it is delivered to the target tissue using electrically enhanced delivery.
Specification