Pacing mode to reduce effects of orthostatic hypotension and syncope

• US 6,662,047 B2
• Filed: 09/05/2001
• Issued: 12/09/2003
• Est. Priority Date: 09/05/2001
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Kroll, Mark W., Bornzin, Gene A., Sorensen, Chris
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US09/947,203
• Publication Number:
  US 20030045910A1
• Time in Patent Office: 825 Days
• Field of Search: 607/2, 607/9, 607/14, 607/17-19, 607/22-27
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable cardiac stimulation device is programmed to administer pacing therapy in response to a change in a patient'"'"'s position and a drop in blood pressure. The stimulation device is equipped with a position sensor to sense a position parameter indicative of when a patient changes from a supine position to an upright position and a pressure sensor to sense a pressure parameter indicative of a patient'"'"'s blood pressure. The device administers cardiac pacing therapy to the patient based on both the position parameter and the pressure parameter.

Claims

1. An implantable cardiac rhythm management device, comprising:

position sensing means for sensing a change in a patient'"'"'s position from a supine position to an upright position;

pressure sensing means for sensing when a patient'"'"'s blood pressure drops below a predefined threshold; and

therapy delivery means, responsive to the position sensing means and the pressure sensing means, for generating cardiac stimulating pulses at an increased rate effective to treat orthostatic hypotension when the patient moves from a supine position to an upright position and the patient'"'"'s blood pressure drops below the predefined threshold.

2. The implantable cardiac rhythm management device of claim 1, wherein the pressure sensing means comprises detecting means for detecting the patient'"'"'s pulse pressure.

3. The implantable cardiac rhythm management device of claim 1, wherein the pressure sensing means comprises monitoring means for monitoring a physiological parameter that can be correlated with the patient'"'"'s blood pressure.

4. The implantable cardiac rhythm management device of claim 1, wherein the therapy delivery means systematically reduces the pulse rate following treatment of the orthostatic hypotension.

5. The implantable cardiac rhythm management device of claim 1, wherein the therapy delivery means systematically reduces the rate of pulses when the patient'"'"'s blood pressure rises above another predefined threshold.

6. A cardiac stimulation device, comprising:

position sensing means for sensing changes in a patient'"'"'s position;

pressure parameter sensing means for sensing a parameter indicative of a patient'"'"'s blood pressure, the pressure parameter sensing means detecting a drop in the patient'"'"'s blood pressure below a predefined threshold; and

therapy administration means, responsive to the position sensing means and the pressure parameter sensing means, for administering cardiac pacing therapy to the patient based on the changes in the patient'"'"'s position and the patient'"'"'s blood pressure dropping below the predefined threshold.

7. The cardiac stimulation device of claim 6, wherein the position sensing means comprises sensing means for sensing a change in a patient'"'"'s position from a supine position to an upright position.

8. The cardiac stimulation device of claim 6, wherein the therapy administration means administers a cardiac pacing therapy effective for combating orthostatic hypotension.

9. The cardiac stimulation device of claim 6, wherein the therapy administration means administers a cardiac pacing therapy effective for combating vasovagal hypotension.

10. A programmable cardiac stimulation device having a memory and a processor, the cardiac stimulation device being programmed to perform tasks comprising:

administering pacing therapy to a patient when the patient experiences both (1) a change in position from a supine position to an upright position and (2) a drop in blood pressure below a predefined threshold; and

subsequently removing the pacing therapy in a systematic manner.

11. The programmable cardiac stimulation device of claim 10, wherein the pacing therapy is removed after a predetermined period of time.

12. The programmable cardiac stimulation device of claim 10, wherein the pacing therapy is removed when the patent experiences a rise in blood pressure above another predefined threshold.

43. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, cause the stimulation device to execute the method of claim 12.

13. A cardiac stimulation device comprising:

a position sensor to sense a position parameter indicative of changes in a patient'"'"'s position;

a pressure sensor to sense a pressure parameter indicative of a patient'"'"'s blood pressure;

a processor operably coupled to the position sensor and the pressure sensor, the processor being configured to determine when to administer cardiac pacing therapy to the patient based on the position parameter and the pressure parameter, the processor being configured to monitor the pressure parameter during administration of the cardiac pacing therapy and to remove the cardiac pacing therapy in response to a change in the pressure parameter; and

a pacing generator configured to administer the cardiac pacing therapy as directed by the processor.

14. The cardiac stimulation device of claim 13, wherein the position sensor comprises a 3D accelerometer.

15. The cardiac stimulation device of claim 13, wherein the position sensor is configured to sense a change from a supine position to an upright position.

16. The cardiac stimulation device of claim 13, wherein the pressure sensor comprises a lead-based pressure sensor that senses a pulse pressure.

17. The cardiac stimulation device of claim 13, wherein the pressure sensor comprises an oxygen sensor.

18. The cardiac stimulation device of claim 13, wherein the pressure sensor comprises a photoplethesmic sensor.

19. The cardiac stimulation device of claim 13, wherein the processor determines to administer cardiac pacing therapy when the position sensor detects a change in the patient'"'"'s position from a supine position to an upright position and the pressure sensor detects a drop in the patient'"'"'s blood pressure.

20. The cardiac stimulation device of claim 19, wherein the pacing generator increases a pacing rate from a first rate to a higher second rate.

21. The cardiac stimulation device of claim 19, wherein the pacing generator generates a pacing rate effective to counteract effects of orthostatic hypotension.

22. The cardiac stimulation device of claim 19, wherein the pacing generator generates a pacing rate effective to counteract effects of vasovagal syncope.

23. The cardiac stimulation device of claim 19, wherein the pacing generator administers the cardiac pacing therapy for a predetermined period of time.

24. An implantable cardiac rhythm management device, comprising:

position sensing means for sensing a change in a patient'"'"'s position;

pressure sensing means for sensing when a patient'"'"'s blood pressure drops below a predefined threshold; and

therapy delivery means for selectively administering pacing therapy to the patient based on the patient'"'"'s position and the patient'"'"'s blood pressure, and for monitoring the patient'"'"'s blood pressure during administration of the pacing therapy and for removing the pacing therapy in response to a change in the patient'"'"'s blood pressure.

25. The implantable cardiac rhythm management device of claim 24, wherein the pressure sensing means comprises detecting means for detecting the patient'"'"'s pulse pressure.

26. The implantable cardiac rhythm management device of claim 24, wherein the therapy delivery means systematically reduces the pulse rate following treatment of vasovagal syncope.

27. The implantable cardiac rhythm management device of claim 24, wherein the therapy delivery means systematically reduces the rate of pulses when the patient'"'"'s blood pressure rises above a predefined threshold.

28. A method comprising:

determining a position parameter indicative of a change in a patient'"'"'s position;

determining a pressure parameter indicative of a patient'"'"'s blood pressure; and

selectively administering pacing therapy to the patient based on the position parameter and the pressure parameter;

wherein the determining a pressure parameter comprises;

monitoring a patient'"'"'s blood pressure; and

detecting a drop in the patient'"'"'s blood pressure below a predefined threshold.

29. The method of claim 28, wherein the administering comprises increasing a cardiac pacing rate from a first pacing rate to a higher second pacing rate.

30. The method of claim 28, wherein the administering comprises administering a pacing therapy effective to counteract effects of orthostatic hypotension.

31. The method of claim 28, wherein the administering comprises administering a pacing therapy effective to counteract effects of vasovagal syncope.

32. The method of claim 28, further comprising systematically removing the pacing therapy after a predetermined amount of time.

33. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, cause the stimulation device to execute the method of claim 28.

34. A method comprising:

determining a position parameter indicative of a change in a patient'"'"'s position;

determining a pressure parameter indicative of a patient'"'"'s blood pressure; and

selectively administering pacing therapy to the patient based on the position parameter and the pressure parameter;

wherein the determining a pressure parameter comprises;

monitoring a physiological parameter that can be correlated with a patient'"'"'s blood pressure; and

detecting a change in the physiological parameter that correlates to a drop in the patient'"'"'s blood pressure below a predefined threshold.

35. A method of administering pacing therapy for orthostatic hypotension, comprising:

detecting a change in a patient'"'"'s position from a supine position to an upright position;

detecting a drop in a patient'"'"'s blood pressure below a predefined threshold; and

adjusting a cardiac pacing rate from a first pacing rate to a second pacing rate effective to counteract effects of orthostatic hypotension in response to detection of the change in the patient'"'"'s position and the drop in the patient'"'"'s blood pressure.

36. The method of claim 35, wherein the detecting a change in the patient'"'"'s position comprises:

monitoring positional data generated by a 3D accelerometer; and

detecting, from the positional data, the change from the supine position to the upright position.

37. The method of claim 35, wherein the detecting a drop in the patient'"'"'s blood pressure comprises:

directly sensing the patient'"'"'s blood pressure; and

ascertaining a drop in the patient'"'"'s blood pressure.

38. The method of claim 35, wherein the detecting a drop in the patient'"'"'s blood pressure comprises:

monitoring a physiological parameter that can be correlated with the patient'"'"'s blood pressure; and

ascertaining a change in the physiological parameter that correlates to a drop in the patient'"'"'s blood pressure.

39. The method of claim 35, wherein the adjusting comprises increasing the cardiac pacing rate from the first pacing rate to the second pacing rate, which is higher than the first pacing rate.

40. The method of claim 35, further comprising adjusting the cardiac pacing rate back toward the first pacing rate.

41. The method of claim 35, further comprising adjusting the cardiac pacing rate back toward the first pacing rate after a predetermined amount of time.

42. The method of claim 35, further comprising:

detecting a rise in the patient'"'"'s blood pressure after said adjusting the cardiac pacing rate; and

in response, adjusting the cardiac pacing rate back toward the first pacing rate.

44. A method of administering pacing therapy for vasovagal syncope, comprising:

detecting a change in a patient'"'"'s position from a supine position to an upright position;

detecting a drop in the patient'"'"'s blood pressure below a predefined threshold; and

adjusting a cardiac pacing rate from a first pacing rate to a second pacing rate effective to counteract effects of vasovagal syncope in response to detection of the change in the patient'"'"'s position and a drop in the patient'"'"'s blood pressure below the predefined threshold.

45. The method of claim 44, wherein the detecting comprises monitoring the patient'"'"'s blood pressure directly.

46. The method of claim 44, wherein the detecting comprises monitoring the patient'"'"'s blood pressure indirectly by sensing a physiological parameter that can be correlated with the patient'"'"'s blood pressure.

47. The method of claim 44, wherein the adjusting comprises increasing the cardiac pacing rate from the first pacing rate to the second pacing rate, which is higher than the first pacing rate.

48. The method of claim 44, further comprising adjusting the cardiac pacing rate back toward the first pacing rate.

49. The method of claim 44, further comprising adjusting the cardiac pacing rate back toward the first pacing rate after a predetermined amount of time.

50. The method of claim 44, further comprising:

detecting a rise in the patient'"'"'s blood pressure above another predefined threshold; and

in response, adjusting the cardiac pacing rate back toward the first pacing rate.

51. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, cause the stimulation device to execute the method of claim 44.

52. A method comprising:

increasing a pacing rate in a cardiac stimulation device from a first rate to a higher second rate when a patient experiences both (1) a change in position from a supine position to an upright position and (2) a drop in blood pressure below a predefined threshold; and

subsequently decreasing the pacing rate back toward the first rate.

53. The method of claim 52, further comprising decreasing the pacing rate after a predetermined period of time.

54. The method of claim 52, further comprising decreasing the pacing rate when the patient experiences a rise in blood pressure above another predefined threshold.

55. One or more computer-readable media having computer-readable instructions thereon which, when executed by a programmable stimulation device, cause the stimulation device to execute the method of claim 52.

56. A method comprising:

determining a position parameter indicative of a change in a patient'"'"'s position;

determining a pressure parameter indicative of a patient'"'"'s blood pressure;

selectively administering pacing therapy to the patient based on the position parameter and the pressure parameter;

monitoring the pressure parameter during administration of the pacing therapy;

systematically removing the pacing therapy in response to a change in the pressure parameter.