Bioactive aneurysm closure device assembly and kit
First Claim
1. An artificial occlusion kit for retaining an artificial occlusion device in a body space to be occluded adjacent to and extending from a body lumen in a mammal, comprising:
- at least one occlusion device for filling at least a portion of the body space; and
a retaining device deliverable and implantable at a retaining site in the body lumen adjacent to the body space, said retaining device having two opposite ends and forming a first shape with a first outer diameter, said retaining device being expandable to a second shape having a second outer diameter larger than said first outer diameter and sufficient to engage a body lumen wall at the retaining site such that a barrier is formed against migration of said at least one occlusion device out of the body space and into the body lumen, said second shape being only partially coated or associated with at least one material effective to cause a localized angiogenic response, said second shape also forming a lumen along a longitudinal axis sufficient to allow flow of fluids therethrough.
9 Assignments
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Accused Products
Abstract
This is an implantable medical device assembly for use in surgical procedures. It is most preferably an implantable structure having stenting properties but only partially coated with or partially associated with a material causing a localized angiogenic response. One variation of is an artificial occlusion kit having the inventive implantable stenting structure situatable and vaso-occlusive devices. The implantable stenting structure is typically situated so to prevent migration of artificial occlusion devices or implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.
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Citations
30 Claims
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1. An artificial occlusion kit for retaining an artificial occlusion device in a body space to be occluded adjacent to and extending from a body lumen in a mammal, comprising:
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at least one occlusion device for filling at least a portion of the body space; and
a retaining device deliverable and implantable at a retaining site in the body lumen adjacent to the body space, said retaining device having two opposite ends and forming a first shape with a first outer diameter, said retaining device being expandable to a second shape having a second outer diameter larger than said first outer diameter and sufficient to engage a body lumen wall at the retaining site such that a barrier is formed against migration of said at least one occlusion device out of the body space and into the body lumen, said second shape being only partially coated or associated with at least one material effective to cause a localized angiogenic response, said second shape also forming a lumen along a longitudinal axis sufficient to allow flow of fluids therethrough. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
a delivery catheter having a proximal delivery catheter end with a proximal delivery port, an opposite distal delivery catheter end portion with a distal delivery port, and a delivery lumen extending between said delivery ports and having a delivery lumen inner diameter less than said second outer diameter, wherein said retaining device is slidably disposable under constraint within said delivery lumen.
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4. The artificial occlusion kit of claim 1 wherein said at least one occlusion device for filling at least a portion of the body space comprises one or more helically wound coils.
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5. The artificial occlusion kit of claim 1 wherein said at least one material effective to cause a localized angiogenic response comprises at least one material which increases cell attachment or thrombogenicity.
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6. The artificial occlusion kit of claim 5 wherein said at least one material which increases cell attachment or thrombogenicity is selected from the group consisting of collagen, fibrinogen, vitronectin, other plasma proteins, growth factors synthetic peptides of these and other proteins having attached RGD (arginine-glycine-aspartic acid) residues (at one or both termini), and cell adhesion peptides.
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7. The artificial occlusion kit of claim 1 wherein said at least one material which increases cell attachment or thrombogenicity is selected from the group consisting of GRGDY, oligonucleotides, full or partial DNA constructs, natural or synthetic phospholipids, and polymers with phosphorylchlorine functionality.
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8. The artificial occlusion kit of claim 1 wherein said at least one material effective to cause a localized angiogenic response comprises at least one material having a polynucleotide sequence encoding a peptide involved in wound healing or promoting cellular attachment.
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9. The artificial occlusion kit of claim 1 wherein said at least one material effective to cause a localized angiogenic response further comprises at least one component having a specific role selected form the group consisting of genes, growth factors, biomolecules, peptides, oligonucletides, members of the integrin family, RGD-containing sequences, and oligopeptides.
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10. The artificial occlusion kit of claim 9 wherein said at least one component having a specific role comprises at least one oligopeptide selected from the group consisting of fibronectin, laminin, vitronectin, hyaluronic acid, acid-elastin, elastin, fibrinogen, and other basement membrane proteins with bioactive activity.
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11. The artificial occlusion kit of claim 1 wherein said at least one material further comprises at least one component having one or more functions, including, but not limited to, providing a therapeutic for local or blood borne delivery, or enhancing thrombosis, coagulation, or platelet activity.
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12. The artificial occlusion kit of claim 1 wherein said at least one material effective to cause a localized angiogenic response comprises one or more polymers.
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13. The artificial occlusion kit of claim 12 wherein said one or more polymers is selected from the group consisting of polyglycolic acid, polylactic acid, reconstituted collagen, poly-p-dioxanone, and their copolymers such as poly(glycolide-lactide) copolymer, poly(glycolide-trimethylene carbonate) copolymer, poly(glycolide-ε
- -caprolactone) copolymer, glycolide-trimethylene carbonate triblock copolymer, and mixtures.
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14. An artificial occlusion kit for occluding a body space adjacent to and extending from a body lumen, the kit comprising:
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at least one occlusion device for filling at least a portion of the body space; and
a retaining device deliverable and implantable at a retaining site in the body lumen adjacent to the body space to retain the at least one occlusion device within the body space, the retaining device comprising;
an expandible structure having a first, non-deployed shape and a second, deployed shape, wherein the retaining device expands from the first shape to the second shape after delivery to the retaining site to engage a body lumen wall at the retaining site, the expandible structure has uniform permeability when in the second shape, and the second shape forms a lumen along a longitudinal axis sufficient to allow flow of fluids therethrough; and
a composition effective to cause a localized angiogenic response, wherein the first shape is coated or partially associated with the composition such that the second shape is only partially coated or partially associated with the composition. - View Dependent Claims (15, 16, 17, 18, 19)
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20. An artificial occlusion kit for occluding a body space adjacent to and extending from a body lumen, the kit comprising:
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at least one occlusion device for filling at least a portion of the body space; and
a coil deliverable and implantable at a retaining site in the body lumen adjacent to the body space to retain the at least one occlusion device within the body space, the coil having a first, non-deployed shape and a second, deployed shape, wherein the coil expands from the first shape to the second shape after delivery to the retaining site, and the second shape being partially coated or associated with a composition effective to cause a localized angiogenic response.
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21. A method of occluding a body space adjacent to and extending from a body lumen, comprising:
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implanting at least one occlusion device in the body space;
delivering a retaining device to the body lumen adjacent to the body space in a first shape, the first shape being coated or associated with a composition effective to cause a localized angiogenic response;
allowing the retaining device to expand from the first shape to a second shape to implant the retaining device in the body lumen, wherein the second shape comprises a structure having a uniform permeability, and the second shape is only partially coated or associated with the composition; and
allowing fluid flow through the retaining device after implantation. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
delivering the retaining device through a delivery catheter, wherein the retaining device is constrained in the first shape within the delivery catheter; and
allowing the retaining device to expand by releasing the retaining device from constraint by pushing the restraining device out of the delivery catheter.
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23. The method of claim 21, wherein the composition coats or is associated with only an exterior surface of the structure of the second shape of the retaining device.
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24. The method of claim 23, wherein the composition coats or is associated with only a portion of the exterior surface.
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25. The method of claim 24, wherein the composition extends only partially along the axial length of the exterior surface.
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26. The method of claim 25, wherein the composition extends only partially around a circumference of the exterior surface.
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27. The method of claim 24, wherein the composition extends only partially around a circumference of the exterior surface.
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28. The method of claim 22, comprising positioning the retaining device such that the portion of the structure of the second shape coated or associated with the composition is adjacent to the body tissue around the body space.
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29. The method of claim 25, wherein the body space is an aneurysm, the method comprising implanting the at least one occlusion device in the aneurysm.
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30. An artificial occlusion kit for occluding a body space adjacent to and extending from a body lumen, the kit comprising:
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at least one occlusion device for filling at lest a portion of the body space; and
a retaining device deliverable and implantable at a retaining site in the body lumen adjacent to the body space to retain the at least one occlusion device within the body space, the retaining device comprising;
an expandible structure having a first, non-deployed shape and a second, deployed shape, wherein the retaining device expands from the first shape to the second shape after delivery to the retaining site to engage a body lumen wall at the retaining site, the expandible structure has uniform permeability when in the second shape, and the second shape forms a lumen along a longitudinal axis sufficient to allow flow of fluids therethrough; and
a composition effective to cause a localized angiogenic response, wherein the first shape is coated or partially associated with the composition such that the second shape is only partially coated or partially associated with the composition.
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Specification