Synchronizing of animal oestrus and intra vaginal devices useful therein

• US 6,663,608 B2
• Filed: 10/11/2001
• Issued: 12/16/2003
• Est. Priority Date: 05/01/1996
• Status: Expired due to Fees

• Current Assignee: Interag
• Original Assignee: Interag
• Inventors: Burggaaf, Shane, Rathbone, Michael John, Bunt, Craig Robert
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Thompson, Michael M
• Application Number:
  US09/973,901
• Publication Number:
  US 20020058926A1
• Time in Patent Office: 796 Days
• Field of Search: 604/890.1, 604/891.1, 604/19, 604/522, 604/57, 604/327-331, 604/364, 604/368, 604/374, 604/385.17, 604/285-288, 604/500, 604/515, 424/486, 528/15
• US Class Current: 604/286
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 9/0036 Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms

Abstract

An intra vaginal device which is of a variable geometry and which includes a silicone matrix impregnated with progesterone, the confirmation and content of the progesterone impregnated matrix being such as to optimise effectiveness with a lower initial loading of progesterone.

Claims

1. A method of postponing oestrus or treating anoestrus in an animal, said method comprising the steps of

moulding a progesterone impregnated silicone rubber matrix having a progesterone content in the matrix of 5% or greater by weight, a total progesterone load of at least one gram, a surface area greater than 75 cm², and at least substantially all of the progesterone in the matrix being less than one millimeter away from a release surface,

administering the progesterone impregnated silicone rubber matrix intra vaginally in the animal,

maintaining the matrix in position until achieving an ultimate progesterone blood plasma level in the animal of from 2 to about 4 nanograms per milliliter, and

removing the device after an insertion period of from 5 to 12 days with a residual load of progesterone in the matrix being less than 65% by weight of an initial progesterone load during the administering step.

2. The method of claim 1, wherein oestradiol is at or near the time of insertion of said device.

3. The method of claim 1, wherein a prostaglandin is administered into the animal at about day 6 of one of about a 7 day and about a 10 day device insertion period.

4. A method of synchronizing the onset of oestrus in a herd of cattle beasts, said method comprising

moulding a progesterone impregnated silicone rubber matrix having a progesterone content in the matrix of 5% or greater by weight, a total progesterone load of at least one gram, a surface area greater than 75 cm², and at least substantially all of the progesterone in the matrix being less than one millimeter away from a release surface, and

administering to each animal from the progesterone impregnated silicone matrix an effective amount of progesterone over a time period of from 5 to 12 days while the matrix is retained intra vaginally such that the matrix is administered with an initial progesterone quantity of about 1.35 grams and is removed with a progesterone quantity of about 0.85 grams thereby producing an ultimate progesterone blood plasma level in the animal of from 2 to about 4 nanograms per milliter.

5. An intra vaginal device capable of being applied into the vaginal cavity of a targeted species animal selected from the group consisting of cattle, sheep, deer and goats, retainable therein over a period of time and then to be withdrawable therefrom to allow the onset of oestrus, said device having

a resilient frame that provides two arms capable of being moved towards each other against the resilience thereof so as, in its vaginal cavity retainable form, to provide an outward pressure reliant upon the vaginal cavity contained splayed condition of the arms thereof, and

one or more masses carried by the frame to provide a matrix of a progesterone impregnated silicon rubber, said matrix

having greater than 5% by weight progesterone to the weight of the matrix,

defining at least one progesterone release surface in total of at least 75 cm² contactable once inserted in the vagina of such an animal by the vaginal membrane and/or vaginal fluid(s) of the animal,

having a total progesterone load, irrespective of whether alpha or beta progesterone or mixtures thereof, of at least 1 gram, and

having at least substantially all of the progesterone in the matrix less than 1 millimeter away from said release surface;

and wherein said device

upon vaginal insertion into such an animal for which it is sized and targeted, is able to achieve and then maintain in the animal for at least seven days a minimum progesterone blood plasma level of 2 nanograms per millimeter of plasma of the animal, and

should the device have been vaginally inserted in such an animal for which it is sized and targeted for seven days, will have a residual load of progesterone in the matrix of less than 65% by weight of its progesterone load at insert.

6. The device as claimed in claim 5 wherein the mass or each mass of the progesterone containing matrix has been formed by injection of uncured progesterone containing matrix as a liquid into a mould for a sufficient time to achieve at an elevated mould temperature a shape retaining at least partial cure thereof.

7. The device as claimed in claim 5 wherein the release surface of the mass or masses of the matrix provide a total progesterone release surface of from 100 to 1500 cm².