Towel graft means for enhancing tissue ingrowth in vascular grafts

• US 6,663,667 B2
• Filed: 10/31/2001
• Issued: 12/16/2003
• Est. Priority Date: 12/29/1999
• Status: Expired due to Term

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Allenberg, Jens, Dehdashtian, Mark
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/002,358
• Publication Number:
  US 20020099441A1
• Time in Patent Office: 776 Days
• Field of Search: 623/1.35, 623/1-9-, 623/1.54
• US Class Current: 623/1.51
• CPC Class Codes: A61F 2/064 with special features to facilitate anastomotic coupling anastomosis of natural blood vessels A61B17/11
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/067 modular
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped

Abstract

A woven vascular graft having a texturized outer surface to promote tissue ingrowth into the graft. The outer surface of the graft is equipped with a plurality of threads that are woven into, and extend from, the outer surface. The threads may be arranged in rows, lines or a geometric pattern. Alternatively, the threads may be towel-like. Such towel-like threads may be arranged in the form of a cuff at each end of the graft, or may cover larger portions of the exterior of the graft. The graft may be equipped with only one texture, or with a plurality of different textures.

Claims

1. A vascular graft adapted for placement in a primary blood vessel, comprising:

a woven tubular structure defining an outer surface characterized by a plurality of thread portions extending from and lying along the exterior of the woven tubular structure, the outer surface being sized to contact and support the blood vessel, wherein the thread portions are selected to increase tissue ingrowth, and further wherein the plurality of thread portions define first and second texture portions.

2. The vascular graft as in claim 1, wherein the thread portions are hoop-like protrusions formed from a filament from at least about 1 cm to about 22 cm in length.

3. The vascular graft as in claim 1, wherein the thread portions are formed from a fiber that is woven into the tubular structure with a picks per inch range of from at least about 138 to about 222.

4. The vascular graft as in claim 1, wherein the configuration of said tubular structure is selected from the group consisting of a straight tube, an aorto-uniliac conversion graft, a bifurcated endoluminal prosthesis, and a thoracic graft device.

5. The vascular graft as in claim 1, wherein the thread portions are selected from the group consisting of vertical thread portions, horizontal thread portions, angled thread portions, loose thread portions and taut thread portions.

6. A vascular graft adapted for placement in a primary blood vessel, comprising:

a woven tubular structure defining an outer surface characterized by a first and a second surface texture and being sized to contact and support the blood vessel, the woven tubular structure having a body portion and first and second cuffs located at first and second ends of the body portion, the cuffs configured to engage the blood vessel and promote tissue ingrowth, and further wherein;

the first surface texture comprises a plurality of thread portions extending generally outwardly from the first and second cuffs, in the form of outwardly extending hoops having a first height, and

the second surface texture comprises a plurality of thread portions extending generally outwardly from the body portion in the form of outwardly extending hoops having a second, different height.

7. The vascular graft as in claim 6, wherein the thread portions are formed from a filament from at least about 1 cm to about 22 cm in length.

8. The vascular graft as in claim 6, wherein the thread portions are formed from a fiber that is woven in the tubular structure.

9. The vascular graft as in claim 6, wherein the hoops of the first surface texture form a dense pile configuration.

10. The vascular graft as in claim 6, wherein the hoops of the second surface texture form elongated strands.

11. The vascular graft as in claim 6, wherein the cuff extends from at least about 1 cm to about 5 cm along the length of the graft.

12. The vascular graft as in claim 6, wherein the configuration of said tubular structure is selected from the group consisting of a straight tube, an aorto-uniliac conversion graft, a bifurcated endoluminal prosthesis, and a thoracic graft device.

13. A vascular graft adapted for placement in a primary blood vessel, comprising:

an elongated woven tubular structure having a first and a second end and an outer surface which is circumferentially reinforced along its length by a plurality of separate, spaced-apart wires, each of which has a generally sinusoidal shape, wherein the outer surface of the graft is characterized by a plurality of differently shaped thread portions extending from the outer surface of the woven tubular structure, the outer surface being sized to contact and support the blood vessel and characterized by a plurality of texture portions, and further wherein the thread portions are configured to increase tissue ingrowth.

14. The vascular graft as in claim 13, the fibers are formed from a filament woven into the tubular structure.

15. The vascular graft as in claim 13, wherein the plurality of thread portions define first and second texture portions, the first texture portion being characterized by a plurality of outwardly extending loop portions and located circumferentially around each end of the woven tubular structure.

16. The vascular graft as in claim 13, wherein the thread portions are selected from the group consisting of vertical thread portions, horizontal thread portions, angled thread portions, loose thread portions and taut thread portions.

17. A method of promoting tissue ingrowth into a tubular graft in a primary blood vessel, comprising:

providing a woven tubular graft having a body portion and an extension portion, wherein the graft has a plurality of fibers extending along the outer surface and forming a texturized outer surface having first and second texture portions;

delivering the tubular graft into an implant position; and

deploying the tubular graft so that the tubular section contacts and supports the blood vessel.

18. The method as in claim 17, wherein the fibers extend into, and are incorporated with, the woven tubular graft.

19. The method as in claim 17, wherein the fibers are formed from a filament that is woven into the tubular structure.

20. The method as in claim 17, wherein the extension portion is characterized by a first texture and the body portion is characterized by a second, different texture extending circumferentially around a central portion of the graft.

21. The method as in claim 20, wherein the first texture is in the form of a plurality of looped thread portions.

22. The method as in claim 20, wherein the second texture comprises a plurality of threads extending along the outer surface and lying parallel to a length of the graft.

23. The method as in claim 20, wherein the second texture comprises a plurality of threads extending along the outer surface and lying perpendicular to a length of the graft.

24. A method of promoting tissue ingrowth into a tubular graft in a primary blood vessel, comprising:

providing an elongated tubular structure having first and second ends and an outer surface sized to contact and support the blood vessel, the tubular structure being circumferentially reinforced along its length by a plurality of separate, spaced-apart wires, each of which has a generally sinusoidal shape, wherein the outer surface of the graft is characterized by a plurality of differently shaped thread portions defining loop members extending from and lying along the outer surface of the woven tubular structure and defining first and second texture portions, and further wherein the thread portions are configured to increase tissue ingrowth;

delivering the tubular graft into an implant position; and

deploying the tubular graft so that the tubular section contacts and supports the blood vessel.

25. The method of promoting tissue ingrowth as in claim 24, wherein the fibers are formed from a filament that is woven into the tubular structure.

26. The method of promoting tissue ingrowth as in claim 24, wherein the configuration of said tubular structure is selected from the group consisting of a straight tube, an aorto-uniliac conversion graft, a bifurcated endoluminal prosthesis, and a thoracic graft device.

27. A vascular graft adapted for placement in a primary blood vessel, comprising:

a woven tubular structure defining an outer surface characterized by a plurality of thread portions extending from and lying along the exterior of the woven tubular structure, the outer surface being sized to contact and support the blood vessel, wherein the thread portions are hoop-like protrusions formed from a filament from at least about 1 cm to about 22 cm in length, and further wherein the thread portions are selected to increase tissue ingrowth.

28. A vascular graft adapted for placement in a primary blood vessel, comprising:

a woven tubular structure defining an outer surface characterized by a plurality of thread portions extending from and lying along the exterior of the woven tubular structure, the outer surface being sized to contact and support the blood vessel, wherein the thread portions are selected to increase tissue ingrowth, and further wherein the thread portions are formed from a fiber that is woven into the tubular structure with a picks per inch range of from at least about 138 to about 222.

29. A vascular graft adapted for placement in a primary blood vessel, comprising:

a woven tubular structure defining an outer surface characterized by a plurality of thread portions extending from and lying along the exterior of the woven tubular structure, the outer surface being sized to contact and support the blood vessel, wherein the thread portions are selected to increase tissue ingrowth, and further wherein the plurality of thread portions define first and second texture portions, the first texture portion being characterized by a plurality of outwardly extending loop portions and located circumferentially around each end of the woven tubular structure.

30. A woven tubular structure defining an outer surface characterized by a plurality of floaters extending from and lying along the exterior of the woven tubular structure, the outer surface being sized to contact and support the blood vessel, wherein each floater extends from the outer surface of the tubular structure at a first point and enters the outer surface of the tubular structure at a second point such that the length of each floater is approximately equal to the distance between the first and second points.