Stable shaped particles of crystalline organic compounds
First Claim
1. A plurality of storage stable particles of uniform shape and size consisting essentially of an allotropic organic compound wherein said allotropic organic compound consists of a uniform crystalline character and a plurality of crystalline domains;
- said organic compound retaining said crystalline character, and said particles retaining said uniform shape and size on storage in aqueous media for at least about one month.
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Abstract
The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1,000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.
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Citations
8 Claims
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1. A plurality of storage stable particles of uniform shape and size consisting essentially of an allotropic organic compound wherein said allotropic organic compound consists of a uniform crystalline character and a plurality of crystalline domains;
- said organic compound retaining said crystalline character, and said particles retaining said uniform shape and size on storage in aqueous media for at least about one month.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
Specification