Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol

• US 6,664,297 B1
• Filed: 10/18/2000
• Issued: 12/16/2003
• Est. Priority Date: 10/18/2000
• Status: Expired due to Fees

• Current Assignee: Universidade Federal do Rio de Janeiro
• Original Assignee: Universidade Federal do Rio de Janeiro
• Inventors: De Felice, Fernanda Guarino, Louzada, Paulo Roberto Ferreira Jr., Ferreira, Sergio Teixeira
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): Willis, Michael A
• Application Number:
  US09/692,743
• Time in Patent Office: 1,154 Days
• Field of Search: 514/728, 514/724, 514/727, 514/731, 514/742
• US Class Current: 514/728
• CPC Class Codes: A61K 31/06 the aromatic ring being substituted by nitro groups

Abstract

The inhibition of the formation and development of amyloidoses, as well as the dissolution of amyloidoses in organisms is claimed. Methods for the diagnosis of amyloidoses using aromatic and heteroaromatic compounds having at least one electron-withdrawing groups are claimed.

Claims

1. A method for promoting the dissolution of existing amyloidoses, the method comprising administration of composition comprising a 2,4-dinitrophenol, or a pharmaceutically acceptable salt thereof, to a patient having amyloidoses in an amount sufficient to inhibit the growth of the amyloidoses or to promote the dissolution of existing amyloidoses.

7. The method of claim 1 or claim 4, wherein patient has Alzheimer'"'"'s Disease.

8. The method of claim 1 or claim 4, wherein patient has diabetes.

9. The method of claim 1 or claim 4, wherein patient has rheumatoid arthritis.

2. A method for inhibiting the formation of amyloidoses, the method comprising

(a) providing a composition comprising a 2,4-dinitrophenol;

and

(b) administering the composition to an individual having amyloidoses in an amount sufficient to inhibit the formation of amyloidoses.

10. The method of claim 2, wherein individual has Alzheimer'"'"'s Disease.

11. The method of claim 2, wherein individual has diabetes.

12. The method of claim 2, wherein individual has rheumatoid arthritis.

3. A method for inhibiting the formation of an amyloid plaque, the method comprising

(a) providing a composition comprising a 2,4-dinitrophenol;

and

(b) contacting the composition with an amyloid plaque, thereby inhibiting the formation of an amyloid plaque.

4. A method for inhibiting the growth of amyloidoses, the method comprising administration of composition comprising a 2,4-dinitrophenol, or a pharmaceutically acceptable salt thereof, to a patient having amyloidoses in an amount sufficient to inhibit the growth of the amyloidoses or to promote the dissolution of existing amyloidoses.

5. A method for inhibiting the growth of an amyloid plaque, the method comprising

(a) providing a composition comprising a 2,4-dinitrophenol;

and

(b) contacting the composition with an amyloid plaque, thereby inhibiting the growth of an amyloid plaque or promoting the dissolution of an amyloid plaque.

6. A method for promoting the dissolution of an amyloid plaque, the method comprising

(a) providing a composition comprising a 2,4-dinitrophenol;

and

(b) contacting the composition with an amyloid plaque, thereby inhibiting the growth of an amyloid plaque or promoting the dissolution of an amyloid plaque.