Cytological imaging system and method
First Claim
Patent Images
1. An optical instrument lighting system, comprising:
- a light source having a first narrow band wavelength for verifying a stain used on a cytological sample; and
the light source having a second narrow band wavelength for viewing the cytological sample, wherein the first narrow band wavelength is different from the second narrow band wavelength.
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Abstract
The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
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Citations
20 Claims
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1. An optical instrument lighting system, comprising:
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a light source having a first narrow band wavelength for verifying a stain used on a cytological sample; and
the light source having a second narrow band wavelength for viewing the cytological sample, wherein the first narrow band wavelength is different from the second narrow band wavelength. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An LED array for use with a system for imaging a stained cytological sample, the imaging system comprising:
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a red LED for verifying the stained sample was stained with a predetermined stain; and
a green LED for illuminating the cytological sample for imaging. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A system for imaging a cytological sample including nuclear material and cytoplasmic material, the system comprising:
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an optical instrument; and
a light source comprising;
a first narrow band wavelength for verifying that the sample was stained with a specific stain, wherein the specific stain transmits light at a wavelength of about 720 nm and a second narrow band wavelength for imaging the sample, wherein the nuclear material transmits light at a wavelength of about 570 nm and the cytoplasmic material is generally minimally visible to the system. - View Dependent Claims (16, 17, 19)
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18. A method for imaging a cell, the method comprising the steps of:
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staining nuclear material of the cell;
staining cytoplasmic material of the cell;
illuminating the cell with a first narrow band wavelength for verifying that a specific stain was used; and
illuminating the cell with a second, narrow band wavelength to image the nuclear material.
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20. A method of imaging a stained cell having nuclear material, the method comprising steps of:
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illuminating the stained cell with a first narrow band wavelength for verifying that a specific stain was used; and
illuminating the stained cell with a second narrow band wavelength to image the nuclear material.
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Specification