Adaptive electric field modulation of neural systems

• US 6,665,562 B2
• Filed: 12/06/2000
• Issued: 12/16/2003
• Est. Priority Date: 12/07/1999
• Status: Expired due to Fees

• Current Assignee: George Mason University
• Original Assignee: George Mason University
• Inventors: Schiff, Steven J., Gluckman, Bruce J.
• Primary Examiner(s): Hoang, Tu Ba
• Application Number:
  US09/729,929
• Publication Number:
  US 20010029391A1
• Time in Patent Office: 1,105 Days
• Field of Search: 607/2, 607/45, 607/116, 607/148, 600/378, 600/545, 128/898
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to the neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of the applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson'"'"'s disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain. The present invention also relates to methods and devices for restoring or repairing a brain function, such as sensation (e.g., taste, or smell), somatic activity, auditory activity, visual activity, or motor activity. It can also be used for testing drugs, pharmacological agents, and other modulators of neuronal function.

Claims

1. A method of treating epilepsy in the brain of a patient in need thereof, comprising:

measuring changes in neuronal activity in said brain within a time period,

applying adaptively, in response to said measured changes in neuronal activity in said brain, a sub-threshold and oriented electric field to the brain of a patient having epilepsy in an amount effective to reduce epileptiform activity of tbe brain,

wherein the electric field is applied through field eLectrodes located in a geometrical arrangement to produce said field in said brain, and

the magnitude and polarity of said electric field are changed continuously in response to the measured changes in neuronal activity within said time period.

2. A method of claim 1, wherein the electric field is applied to the brain when epileptiform activity is detected through measuring electrodes.

3. A method of claim 1, wherein the applied electric field is under full-wave control.

4. A method of claim 1, wherein the applied electric field is half-wave rectified.

5. A method of claim 1, wherein the applied electric field is proportional to the measured changes in neuronal activity.

6. A method of claim 1, wherein the measuring changes in neuronal activity is performed simultaneously and continuously with the applied electric field.

7. A method of claim 1, wherein the applied field is proportional to the difference between the root-mean-square of the measured changes in neuronal activity and a predetermined threshold activity value in a predetermined frequency band.

8. A method of claim 1, wherein the measured changes in neuronal activity is represented as the root-mean-square within a frequency band of 100-500 Hz, averaged over a set time period.

9. A method of claim 1, wherein the applied electric field modifies the firing rate of the neurons in the brain.

10. A method of claim 1, wherein the field electrodes are located radially.

11. A method of treating Parkinson'"'"'s disease in a patient in need thereof, comprising:

applying adaptively, in response to tremors, rigidity, or difficulty in initiating movement, a sub-threshold and oriented electric field to the brain of a patient having Parkinson'"'"'s disease in an amount effective to reduce said tremors, rigidity, or difficulty in initiating movement, wherein the electric field is applied through field electrodes in contact with the brain, and

the magnitude and polarity of said electric field are changed continuously in response to said tremors, rigidity, or difficulty in initiating movement within a time period.