Pharmaceutical compositions containing an effervescent acid-base couple
First Claim
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1. A pharmaceutical composition in form of effervescent or fast-dissolving tablet of a water-soluble blend comprising an active ingredient and an effervescent couple, the couple comprising an acidic component and an alkaline component, wherein the active ingredient is selected from the group consisting of piroxicam-β
- -cyclodextrin complex, ambroxol hydrochloride, piroxicam combined with a cyclodextrin as an excipient, and apomorphine hydrochloride, the acidic component is selected from the group consisting of fumaric acid, maleic acid and their salts and the alkaline component is sodium glycine carbonate.
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Abstract
A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate to release carbon dioxide.
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Citations
13 Claims
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1. A pharmaceutical composition in form of effervescent or fast-dissolving tablet of a water-soluble blend comprising an active ingredient and an effervescent couple, the couple comprising an acidic component and an alkaline component, wherein the active ingredient is selected from the group consisting of piroxicam-β
- -cyclodextrin complex, ambroxol hydrochloride, piroxicam combined with a cyclodextrin as an excipient, and apomorphine hydrochloride, the acidic component is selected from the group consisting of fumaric acid, maleic acid and their salts and the alkaline component is sodium glycine carbonate.
- View Dependent Claims (2, 8, 10, 12, 13)
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3. A pharmaceutical composition in form of effervescent or fast-dissolving tablet of a water-soluble blend comprising an active ingredient and an effervescent couple, the couple comprising an acidic component and an alkaline component, wherein the active ingredient is selected from the group consisting of piroxicam-β
- -cyclodextrin complex, ambroxol hydrochloride and piroxicam combined with a cyclodextrin as an excipient, the acidic component is selected from the group consisting of fumaric acid, maleic acid and their salts and the alkaline component is sodium glycine carbonate.
- View Dependent Claims (4, 7, 11)
- 5. A pharmaceutical composition in form of effervescent or fast-dissolving tablet of a water-soluble blend comprising an active ingredient and an effervescent couple, the couple comprising an acidic component and an alkaline component, wherein the active ingredient is apomorphine hydrochloride, the acidic component is selected from the group consisting of fumaric acid, maleic acid and their salts and the alkaline component is sodium glycine carbonate.
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9. A pharmaceutical composition in form of effervescent or fast-dissolving tablet comprising an active ingredient and an effervescent couple, the couple comprising an acidic component and an alkaline component, wherein the active ingredient is apomorphine hydrochloride, the acidic component is fumaric acid, or its salts and the alkaline component is sodium glycine carbonate and further comprising mannitol, crosspovidone and magnesium stearate.
Specification