Methods for treating neuropsychiatric disorders
First Claim
1. A method for treating autism, the method comprising administering to a patient diagnosed as suffering from autism a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of D-alanine, a salt of D-alanine, an ester of D-alanine, an alkylated D-alanine, a precursor of D-alanine, D-serine, a salt of D-serine, an alkylated D-serine, a precursor of D-serine, D-cycloserine, a salt of D-cycloserine, an ester of D-cycloserine, a precursor of D-cycloserine, an alkylated D-cycloserine, N-methylglycine, a salt of N-methylglycine, an ester of N-methylglycine, an alkylated N-methylglycine, and N,N,N-trimethylglycine.
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Accused Products
Abstract
The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer'"'"'s Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).
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Citations
59 Claims
- 1. A method for treating autism, the method comprising administering to a patient diagnosed as suffering from autism a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of D-alanine, a salt of D-alanine, an ester of D-alanine, an alkylated D-alanine, a precursor of D-alanine, D-serine, a salt of D-serine, an alkylated D-serine, a precursor of D-serine, D-cycloserine, a salt of D-cycloserine, an ester of D-cycloserine, a precursor of D-cycloserine, an alkylated D-cycloserine, N-methylglycine, a salt of N-methylglycine, an ester of N-methylglycine, an alkylated N-methylglycine, and N,N,N-trimethylglycine.
- 31. A method for treating schizophrenia, the method comprising administering to a patient diagnosed as suffering from schizophrenia a pharmaceutical composition comprising a compound selected from the group consisting of D-serine, a salt of D-serine, an ester of D-serine, an alkylated D-serine, and a precursor of D-serine, wherein the pharmaceutical composition is administered at a dose equivalent to 100 mg to 10 g D-serine per day.
- 45. A method for treating a positive symptom of schizophrenia, the method comprising administering to a patient diagnosed as suffering from a positive symptom of schizophrenia a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of D-serine, a salt of D-serine, an ester of D-serine, an alkylated D-serine, and a precursor of D-serine.
Specification