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Printing oligonucleotide arrays

  • US 6,667,394 B2
  • Filed: 04/24/2001
  • Issued: 12/23/2003
  • Est. Priority Date: 02/27/1995
  • Status: Expired due to Fees
First Claim
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1. A method of forming selected polymers on a substrate, said method comprising:

  • providing a substrate comprising a layer of linker molecules thereon, each of said linker molecules having a protective group at its distal end away from the substrate;

    applying a barrier layer overlying said linker molecule layer, said applying step forming selected exposed regions of said linker molecule layer;

    exposing said selected exposed regions of said linker molecule layer to a deprotecting agent in a vapor phase, wherein said vapor phase removes more than 80% of the protective groups in said selected exposed regions; and

    coupling selected monomers to form said selected polymers on the substrate.

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