Thermally-activated microchip chemical delivery devices

• US 6,669,683 B2
• Filed: 01/13/2003
• Issued: 12/30/2003
• Est. Priority Date: 08/18/1999
• Status: Expired due to Term

• Current Assignee: Microchips Biotech, Inc. (Keratin Biosciences, Inc.)
• Original Assignee: MicroCHIPS Inc.
• Inventors: Cima, Michael J., Santini, John T. Jr., Uhland, Scott Albert
• Primary Examiner(s): Tanner, Harry B.
• Application Number:
  US10/341,305
• Publication Number:
  US 20030105455A1
• Time in Patent Office: 351 Days
• Field of Search: 604/890.1, 604/891.1, 604/892.1, 604/19, 216/2, 216/39, 216/56
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2400/0677 phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/50853 with covers or lids

Abstract

Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

Claims

1. An implantable microchip device for the controlled delivery of drug molecules into a patient comprising:

at least one substrate;

a plurality of reservoirs in the substrate;

a release system which includes drug molecules for release, the release system being provided in each of the reservoirs;

a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and

a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs.

2. The device of claim 1, wherein the drug molecules comprise proteins, nucleic acids, or polysaccharides.

3. The device of claim 1, wherein the drug molecules comprise synthetic organic molecules.

4. The device of claim 1, wherein the drug molecules comprise an anesthetic, a vaccine, a chemotherapeutic agent, a metabolite, a sugar, an immunomodulator, an antioxidant, an ion channel regulator, an antibiotic, or a combination thereof.

5. The device of claim 1, wherein the drug molecules comprise a hormone.

6. The device of claim 1, which provides pulsatile release of the drug molecules.

7. The device of claim 1, which provides continuous release of the drug molecules.

8. The device of claim 1, wherein the release system comprises the drug molecules distributed in a matrix formed of a degradable material.

9. The device of claim 1, wherein the release system comprises the drug molecules distributed in a matrix formed of a polymeric material.

10. The device of claim 1, wherein the release system comprises the drug molecules in a solid form.

11. The device of claim 1, wherein the release system comprises the drug molecules in a liquid solution.

12. The device of claim 1, wherein the release system comprises a pharmaceutically acceptable carrier or excipient.

13. The device of claim 12, wherein the release system comprises an inorganic excipient or diluent.

14. The device of claim 12, wherein the release system comprises an organic excipient or diluent.

15. The device of claim 1, wherein the reservoir cap comprises a metal thin film.

16. The device of claim 1, wherein the reservoir cap further comprises an overcoat material.

17. The device of claim 16, wherein the overcoat material comprises a biodegradable polymer.

18. The device of claim 1, wherein the heating means comprises a thin film resistor.

19. The device of claim 1, further comprising a timer, a demultiplexer, a microprocessor, a power source, and an input source, which cooperate to control the heating means.

20. The device of claim 19, wherein the input source comprises a memory source, a signal receiver, or a biosensor.

21. The device of claim 1, further comprising a biosensor integrated into the device capable of detecting molecules in a fluid surrounding the device.

22. A method for the controlled delivery of a drug to a patient comprising:

implanting into a patient a microchip device which comprises at least one substrate, a plurality of reservoirs in the substrate, a release system which includes drug molecules for release, the release system being provided in each of the reservoirs, a reservoir cap positioned on or in each of the reservoirs over the release system wherein the reservoir cap comprises a material that undergoes a phase change in response to a change in temperature, and a heating means capable of selectively causing the phase change independently in each reservoir cap; and

selectively activating the heating means to heat at least one of the reservoir caps in an amount effective to cause a phase change in, and removal of, said at least one reservoir cap to release the drug molecules from at least one corresponding reservoir and into the patient.

23. The method of claim 22, wherein the drug molecules comprise proteins, nucleic acids, or polysaccharides.

24. The method of claim 22, wherein the drug molecules comprise synthetic organic molecules.

25. The method of claim 22, wherein the drug molecules comprise an anesthetic, a vaccine, a chemotherapeutic agent, a metabolite, a sugar, an immunomodulator, an antioxidant, an ion channel regulator, an antibiotic, or a combination thereof.

26. The method of claim 22, wherein the drug molecules comprise a hormone.

27. The method of claim 22, wherein the drug molecules are released in a pulsatile manner.

28. The method of claim 22, wherein the drug molecules are released in a continuous manner.

29. The method of claim 22, wherein the release system comprises the drug molecules distributed in a matrix formed of a degradable material.

30. The method of claim 22, wherein the release system comprises the drug molecules distributed in a matrix formed of a polymeric material.

31. The method of claim 22, wherein the release system comprises the drug molecules in a solid form.

32. The method of claim 22, wherein the release system comprises the drug molecules in a liquid solution.

33. The method of claim 22, wherein the reservoir cap comprises a metal thin film.

34. The method of claim 22, wherein the reservoir cap further comprises an overcoat material.

35. The method of claim 34, wherein the overcoat material is substantially removed from the reservoir cap before the change in phase of the reservoir cap to release the drug molecules.

36. The method of claim 35, wherein the overcoat material comprises a water soluble or biodegradable polymer.

37. The method of claim 22, wherein the heating means comprises at least one thin film resistor for heating each reservoir cap.

38. The method of claim 22, wherein the microchip device further comprises a timer, a demultiplexer, a microprocessor, a power source, and an input source, which cooperate to control the heating means.

39. The method of claim 22, wherein the input source comprises a memory source, a signal receiver, or a biosensor.

40. The method of claim 22, wherein the microchip device further comprises a biosensor capable of detecting molecules in a fluid surrounding the implanted microchip device.

41. The method of claim 22, wherein the phase change comprises melting.

42. The method of claim 22, wherein the phase change comprises vaporization.

43. A microchip device for the controlled release of molecules in vitro in analytical chemistry or medical diagnostics comprising:

at least one substrate;

a plurality of reservoirs in the substrate;

a release system which includes molecules for release, the release system being provided in each of the reservoirs, and the molecules for release comprising a diagnostic agent or a reagent in a reaction for an analytical procedure or medical diagnostic procedure;

a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and

a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs.

44. A method for the controlled release of molecules in vitro in analytical chemistry or medical diagnostics comprising:

providing the device of claim 43 at a site in vitro; and

selectively activating the heating means to heat at least one of the reservoir caps in an amount effective to cause a phase change in, and substantial removal of, said at least one reservoir cap to release the molecules from at least one corresponding reservoir at the site.

45. The method of claim 44, wherein the molecules comprise a reagent for use in a polymerase chain reaction or other nucleic acid amplification procedure.

46. A microchip device for the controlled release of molecules in vitro comprising:

at least one substrate;

a plurality of reservoirs in the substrate;

a release system which includes molecules for release, the release system being provided in each of the reservoirs, and the molecules for release comprising perfumes, fragrances, dyes, coloring agents, or sweeteners;

a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and

a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs.

47. A method for the controlled release of molecules in vitro comprising:

providing at a site in vitro a microchip device which comprises at least one substrate, a plurality of reservoirs in the substrate, a release system which includes vaporizable molecules for release, the release system being provided in each of the reservoirs, a reservoir cap positioned on or in each of the reservoirs over the release system wherein the reservoir cap comprises a material that undergoes a phase change in response to a change in temperature, and a heating means capable of selectively causing the phase change independently in each reservoir cap;

selectively activating the heating means to heat at least one of the reservoir caps in an amount effective to cause a phase change in, and substantial removal of, said at least one reservoir cap; and

vaporizing the vaporizable molecules to release the molecules from at least one corresponding reservoir to said site.