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Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers

  • US 6,669,831 B2
  • Filed: 05/10/2001
  • Issued: 12/30/2003
  • Est. Priority Date: 05/11/2000
  • Status: Expired due to Term
First Claim
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1. A method of inducing high bulk hydrodynamic resistance in a microfluidic device, the method comprising:

  • providing at least one microscale cavity in the microfluidic device;

    introducing a fluid into the microscale cavity, the fluid comprising an analyte and at least one bulk viscosity enhancer, wherein the at least one bulk viscosity enhancer effects an increase in bulk hydrodynamic resistance of the fluid within the at least one microscale cavity, thereby inducing high bulk hydrodynamic resistance in the microfluidic device.

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