Systems and methods for collecting plasma that is free or virtually free of cellular blood species

• US 6,669,905 B1
• Filed: 03/31/2000
• Issued: 12/30/2003
• Est. Priority Date: 05/21/1998
• Status: Expired due to Term

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc.
• Inventors: Blom, Agneta, Mespreuve, Luc, Vandendaul, Daniel, Payrat, Jean-Marc, Mathias, Jean Marie
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/540,935
• Time in Patent Office: 1,369 Days
• Field of Search: 604/4.01, 604/5-1-, 604/6-1-, 604/6.08, 604/6.09, 604/6.15, 604/6.16, 604/28, 604/45, 604/500, 604/506, 604/507, 604/257, 604/258, 604/262, 604/317, 604/326-27, 604/403, 604/405-6, 604/408, 604/411-16, 604/903, 422/1, 422/22, 422/24, 422/40-44, 210/634, 210/639, 210/641, 210/435-37, 210/503, 210/644, 210/649-51, 210/767, 210/781, 210/782, 210/789, 210/252, 210/255, 210/257--25, 210/294, 210/295, 210/323.1, 210/334, 210/348, 210/472, 210/500.1, 210/505
• US Class Current: 422/44
• CPC Class Codes: A61L 2/04 Heat A61L2/08 takes precedence
• CPC Class Codes: A61M 1/0222 and filter bypass
• CPC Class Codes: A61M 1/0227 and means for securing the filter against damage, e.g. during centrifugation
• CPC Class Codes: A61M 1/0231 with gas separating means, e.g. air outlet through microporous membrane or gas bag
• CPC Class Codes: A61M 1/3633 Blood component filters, e.g. leukocyte filters
• CPC Class Codes: A61M 1/3636 having a flexible housing
• CPC Class Codes: A61M 2202/0092 starting product created by centrifuging
• CPC Class Codes: A61M 2202/0429 Red blood cells; Erythrocytes
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

Systems and methods treat plasma by separating targeted blood cell species such as red blood cells and platelets from the plasma by filtration through hydrophilic polyvinylidene fluoride (PVDF) membranes.

Claims

1. A system for treating plasma comprising

tubing adapted to be coupled to a source of plasma to convey plasma from the source,

a filter in the tubing to separate aggregates and targeted cellular blood species including red blood cells and platelets from plasma conveyed from the source container, the filter including a prefilter that removes aggregates from plasma, the filter further including, arranged sequentially in a downstream flow direction from the prefilter, first and second hydrophilic polyvinylidene fluoride (PVDF) membranes having pores sized to remove the targeted cellular blood species from plasma by exclusion, the pores of the first PVDF membrane being about 1.0 m in average size and having a porosity that is characterized by a water bubble point of between about 8.5 psi and 13 psi, the pores of the second PVDF membrane being about 0.65 m in average size and having a porosity that is characterized by a water bubble point of between about 15.5 psi and 20.6 psi.

2. A system according to claim 1

and further including a transfer container coupled to the tubing to receive plasma after passage through the filter.

3. A system according to claim 2

further including a photoactive material in the transfer container.

4. A system according to claim 1

wherein the filter includes a flexible housing enclosing the prefilter layer and the first and second PVDF membranes.

5. A system according to claim 4

wherein the filter includes, enclosed within the flexible housing, a mesh layer arranged in a downstream flow direction from the first and second PVDF membranes.

6. A system according to claim 1

wherein the prefilter layer includes glass fiber.

7. A method for treating plasma comprising the steps of

harvesting plasma from whole blood, and

removing all or virtually all of red blood cells and platelets from the plasma by filtration through a prefilter that removes aggregates from plasma and, arranged sequentially in a downstream flow direction from the prefilter, porous first and second hydrophilic polyvinylidene fluoride (PVDF) membranes, the first PVDF membrane having pores about 1.0 μ

m in average size and having a porosity that is characterized by a water bubble point of between about 8.5 psi and 13 psi, the second PVDF membrane having pores about 0.65 μ

m in average size and having a porosity that is characterized by a water bubble point of between about 15.5 psi and 20.6 psi.

8. A method according to claim 7

wherein the plasma is harvested in a manual blood collection system.

9. A method according to claim 7

wherein the plasma is harvested in a blood separation device in an on-line extracorporeal circuit.

10. A method according to claim 7

further including the steps of adding to the plasma a photoactive material, and emitting radiation at a selected wavelength into the plasma to activate the photoactive material.