Devices comprising multiple capillarity inducing surfaces

• US 6,669,907 B1
• Filed: 07/10/2000
• Issued: 12/30/2003
• Est. Priority Date: 11/15/1996
• Status: Expired due to Term

• Current Assignee: BIOSITE INCORPORATED (Abbott Laboratories)
• Original Assignee: BIOSITE INCORPORATED (Abbott Laboratories)
• Inventors: Buechler, Kenneth Francis
• Primary Examiner(s): Ludlow, Jan
• Application Number:
  US09/612,815
• Time in Patent Office: 1,268 Days
• Field of Search: 422/55-61, 422/100, 422/102
• US Class Current: 422/420
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence

Abstract

Assay device structures for a device where fluid flows from a one region to another. The device structures comprising one or more capillarity-inducing structures; where the capillarity-inducing structure induces capillary force along an axis that is essentially perpendicular to the axis along which capillary force induced in another region of the device.

Claims

1. An assay device comprising:

a housing defining a proximal region and a distal region, wherein;

a) capillarity in the proximal region is induced by a first surface of said housing and a second surface of said housing along a first axis defined by a normal from said first surface to said second surface;

b) capillarity in the distal region is induced by a plurality of capillarity-inducing structures, each comprising a perimeter surface discontinuous with perimeter surfaces of adjacent capillarity-inducing structures, said distal region capillarity arising along a second axis between opposing perimeter surfaces of adjacent capillarity-inducing structures;

c) said first axis is substantially perpendicular to said second axis such that the opposing perimeter surfaces that induce capillary force in the distal region have a different positional orientation relative to the opposing surfaces of the proximal region; and

d) said proximal and distal regions are configured and arranged to provide an effective capillary force in the distal region that is approximately equal to or greater than an effective capillary force in the proximal region, and to provide a fluid flow path from said proximal to said distal region.

2. The device of claim 1 wherein the device comprises a regular array of capillarity-inducing structures.

3. The device of claim 2 wherein each capillarity-inducing structure of the array is substantially uniform.

4. The device of claim 2 wherein each capillarity-inducing structure of the array is located an essentially uniform distance from each adjacent capillarity-inducing structure.

5. The device of claim 1 wherein the capillarity-inducing structures comprise an essentially hexagonal configuration when viewed along at least one plane.

6. The assay device of claim 1 wherein fluid introduced into said proximal region flows from the proximal region to the distal region without application of an external force.

7. The device of claim 6 further comprising that said proximal region comprises a lower effective capillarity than the distal region.

8. The device of claim 6 further comprising that said proximal region comprises similar capillarity relative to the distal region do that fluid will flow between the proximal and distal regions.

9. The device of claim 6 wherein the distal region comprises a regular array of capillarity-inducing structures.

10. The device of claim 9 wherein each structure of the array is regularly spaced relative to adjacent capillarity-inducing structures.

11. The device of claim 6 wherein the capillary-inducing structures comprise an essentially uniform configuration taken along any a cross-sectional dimension.

12. The device of claim 6 wherein the distal region comprises an essentially regularly spaced array of essentially uniformly hexagonally shaped capillarity-inducing structures, when viewed from a perspective essentially perpendicular to a direction of capillary fluid flow through the device.