Template-textured materials, methods for the production and use thereof

• US 6,670,427 B1
• Filed: 03/26/2001
• Issued: 12/30/2003
• Est. Priority Date: 08/03/1998
• Status: Expired due to Fees

• Current Assignee: Poly-An GmbH
• Original Assignee: Poly-Am GmbH
• Inventors: Piletski, Sergiy, Ulbricht, Mathias, Schedler, Uwe, Matuschewski, Heike
• Primary Examiner(s): Seidleck, James J.
• Assistant Examiner(s): Asinovsky, Olga
• Application Number:
  US09/762,357
• Time in Patent Office: 1,009 Days
• Field of Search: 525/330.3, 525/54.11, 525/263, 525/273, 522/1
• US Class Current: 525/330.3
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/265 modified or post-treated polymers polymer carriers or substrates subjected to further impregnating or coating B01J20/3208
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/268 Polymers created by use of a template, e.g. molecularly imprinted polymers
• CPC Class Codes: B01J 20/28016 Particle form
• CPC Class Codes: B01J 20/28021 Hollow particles, e.g. hollow spheres, microspheres or cenospheres
• CPC Class Codes: B01J 20/28023 Fibres or filaments fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence
• CPC Class Codes: B01J 20/28033 Membrane, sheet, cloth, pad, lamellar or mat
• CPC Class Codes: B01J 20/28078 Pore diameter

Abstract

Template-textured materials in the form of template-textured polymers (TGP) on various surfaces including membranes (i.e, template-textured membranes). Such materials are created by modifying the surface of solid carriers, which, by cross-linking polymerization of functional monomers initiated on the surface of said solid carriers in the presence of a template, leads to stable template prints that subsequently bind template molecules or template derivatives in a specific manner. The invention also relates to methods for the production of TGPs and to the use thereof for substance-specific separation of materials.

Claims

1. A template-textured material comprising a template-textured polymer bound directly and covalently to a surface of a solid carrier, said template-textured material being capable of specifically binding a template and being obtained by modifying the surface of the solid carrier in an organic or an aqueous or aqueous-saline solution by heterogeneous photoinitiated cross-linking graft polymerization of functional monomers on said surface in the presence of said template, said heterogeneous photoinitiated cross-linking graft polymerization using a substance of the H-abstraction feature as a photoinitiator and the solid carrier as a co-initiator.

2. The template-textured material according to claim 1, wherein the solid carrier is a membrane.

3. The template-textured material according to claim 1, characterized in that a chemically initiated cross-linking polymerization of functional monomers proceeds on the carrier surface.

4. The template-textured material according to claim 3, characterized in that a substance is used as initiator, which after a physical or chemical excitation generates radicals or other initiator species for a polymerization.

5. The template-textured material according to any of claims 1, 2, 3, or 4, characterized in that organic polymers polymerized from a member of the group consisting of polypropylene, polyethylene, polystyrene, polysulfone, polyamide, polyester, polycarbonate, polyacrylnitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyacrylates, polyacrylamides, cellulose, amylose, agarose, and mixtures thereof as well as their respective derivatives, copolymers or blends of said polymers are used as carrier materials or as membrane materials.

6. The template-texture material according to any of claims 1, 2, 3, or 4, wherein the solid carriers are solid porous bodies, wherein the solid porous bodies are a member selected from the group consisting of glasses, silicates, ceramics, metals and composites thereof, and organic polymers.

7. A method for the production of template-textured materials comprising modifying a surface of a solid carrier in an organic or an aqueous or aqueous-saline solution by heterogeneous photoinitiated cross-linking graft polymerization of functional monomers on said surface in the presence of a template, said heterogeneous photoinitiated cross-linking graft polymerization using a substance of the H-abstraction feature as a photoinitiator and the solid carrier as a co-initiator.

8. The method according to claim 7, characterized in that the carrier material comprises a membrane.

9. The method according to claim 8, characterized in that a substance is used as initiator which generates radicals or other initiator species for a polymerization subsequent to a physical or chemical excitation.

10. The method according to claim 7 or 8, characterized in that the carrier materials or the membrane materials are

a) a member of the group consisting of polypropylene, polyethylene, polystyrene, polysulfone, polyamide, polyester, polycarbonate, polyacrylnitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyacrylates, polyacrylamides, cellulose, amylose, agarose, and mixtures thereof as well as their respective derivatives, copolymers or blends of said polymers;

b) solid porous bodies forming a member of the group consisting of glasses, silicates, ceramics, metals and composites thereof, and organic polymers.

11. The method according to claim 7, characterized in that as carriers, films, membranes, fibres, hollow fibres, fabrics, fleeces or particles, in each case non-porous or porous, are used.

12. The method according to claim 8, characterized in that template-textured membranes are synthesized starting from a porous membrane with maintenance of the macroporous structure and the specific surface.

13. The method according to claim 8, characterized in that membranes are used having symmetrical but also asymmetrical pore structure and pore sizes between about 2 nm and 10 μ

m.

14. The method according to claim 7 or 8, wherein small molecules having molecular weights of below or about 100 Da and being a member selected from the group consisting of herbicides, drugs or amino-acids, wherein larger molecules and being a member selected from the group consisting of peptides, proteins, nucleic acids or carbohydrates, and wherein particles selected from the group consisting of viruses, bacteria and cells, serve as templates.

15. The method according to claim 7 or 8, characterized in that polymerizable compounds having groups enabled for interacting with templates, in particular groups comprising carboxyl, sulfonyl, sulfate, phosphate, amino or quarternary ammonium, as well as their respective derivatives, even in mixtures thereof, are used as functional monomers.

16. The method according to claim 7 or 8, characterized in that the binding specificity and binding capacity of the template-textured polymer is increased for the template as well as for template-similar substances by addition of salt.

17. The method according to claim 7 or 8, characterized in that the template is not removed from the template imprints subsequent to synthesis.

18. A method for separating a material and/or analytic of a liquid or gaseous substance mixture, said method comprising

exposing said liquid or gasous substance mixture to a template-textured material by perfusion or diffusion of the liquid or gaseous substance mixture through the template-textured material or the application of the liquid or gaseous substance mixture onto the template-textured material, said template-textured material being obtained by modifying a surface of a solid carrier in an organic or an aqueous or aqueous-saline solution by heterogeneous photoinitiated cross-linking graft polymerization of functional monomers on said surface in the presence of a template for said material and/or analytic, said heterogeneous photoinitiated cross-linking graft polymerization using a substance of the H-abstraction feature as a photoinitiator and the solid carrier as a co-initiator.

19. The method according to claim 18, wherein the template-textured material is used to separate the material and/or analytic from the liquid or gaseous substance mixture by affinity filtration.

20. The method according to claim 18 wherein the template-textured material is used to separate the material and/or analytic from the liquid or gaseous substance mixture by dialysis or electrodialysis.

21. The method according to claim 18 wherein the template-textured material is used to separate the material or analytic from the liquid or gaseous substance mixture by solid phase extraction, chromatography, membrane chromatography or electrophoresis.