Closed loop neuromodulation for suppression of epileptic activity
First Claim
Patent Images
1. A method comprising:
- delivering electrical stimuli to a structure of a brain;
sensing response field potentials evoked by the stimuli delivered to the structure; and
analyzing the sensed response field potentials to predict the likelihood of occurrence of a neurological disorder.
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Abstract
A system and method for predicting the likelihood of occurrence of an impending neurological episode. Electrical stimuli are delivered to a structure of the brain. Response field potentials evoked by the stimuli are sensed. Analysis of these field potentials allows for predictions as to the occurrence of an impending, but not yet occurring, neurological disorder. In one example, a measurement of change in response pulses is used to determine a level of interconnectivity in the structures of the brain. The level of functional interconnectivity is used in predicting the occurrence of the neurological event. An example of such a neurological event includes an epileptic seizure.
247 Citations
95 Claims
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1. A method comprising:
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delivering electrical stimuli to a structure of a brain;
sensing response field potentials evoked by the stimuli delivered to the structure; and
analyzing the sensed response field potentials to predict the likelihood of occurrence of a neurological disorder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
measuring a field potential evoked by the first stimulus and the field potential evoked by the second stimulus at the first and second location; and
determining a level of functional interconnectivity from a ratio of the response field potentials measured at the first and second locations.
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16. The method of claim 15, wherein analyzing the sensed response field potentials includes indicating a likely epileptic event when the level of functional interconnectivity exceeds a predetermined threshold value.
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17. The method of claim 15, wherein analyzing the sensed response field potentials includes indicating a likely epileptic event when the level of functional interconnectivity has a negative slope.
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18. The method of claim 5, including delivering a therapy for the neurological disorder when the change in the response field potentials exceeds a threshold value.
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19. The method of claim 18, wherein delivering the therapy includes delivering therapy pulses at a high frequency to prevent the occurrence of the neurological disorder.
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20. The method of claim 1, wherein analyzing the sensed response field potentials includes analyzing the sensed response field potentials pulses to predict the likelihood of occurrence of an epileptic seizure.
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21. The method of claim 1, wherein delivering stimuli to the structure includes delivering a predetermined number of stimuli to the structure.
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22. The method of claim 1, wherein delivering stimuli to the structure includes delivering the stimuli to an afferent fiber or efferent fiber system in the structure of the brain.
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23. A method comprising:
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implanting one or more electrodes in a structure of a brain;
delivering electrical stimuli to the structure through the electrodes;
sensing response field potentials evoked by the stimuli delivered to the structure;
processing the response field potentials to predict the likelihood of occurrence of a neurological disorder based on the sensed response field potentials. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
measuring a field potential evoked by the first stimulus and the field potential evoked by the second stimulus at the first and second location; and
determining a level of functional interconnectivity from a ratio of the response field potentials measured at the first and second locations.
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42. The method of claim 41, wherein processing the response field potentials includes indicating a likely epileptic event when the level of functional interconnectivity exceeds a predetermined threshold value.
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43. The method of claim 41, wherein processing the response field potentials includes indicating a likely epileptic event when the level of functional interconnectivity has a negative slope.
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44. The method of claim 31, including delivering a therapy for the neurological disorder when the change in the response field potential exceeds a threshold value.
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45. The method of claim 44, wherein delivering the therapy includes delivering therapy pulses at a high frequency to prevent the occurrence of the neurological disorder.
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46. The method of claim 23, wherein processing the response field potentials includes identifying the occurrence of an epileptic seizure based on the sensed response field potentials.
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47. The method of claim 23, wherein delivering stimuli to the structure includes delivering the stimuli to an afferent fiber or an efferent fiber system in the structure of the brain.
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48. A system comprising:
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one or more electrodes implantable in a structure of a brain;
a signal processor/generator coupled to the electrodes, wherein the signal generator includes;
an electrical pulse generator to deliver electrical stimuli to the brain via the electrodes implanted in the structure of the brain; and
a signal analyzer to receive via the electrodes response field potentials to the electrical stimuli delivered with the electrical pulse generator, where the signal analyzer receives response field potentials through the electrodes and predicts the likelihood of the occurrence of a neurological disorder based on the sensed response field potentials. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A system comprising:
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means for delivering electrical stimuli to a structure of a brain;
means for sensing response field potentials evoked by the stimuli delivered to the structure; and
means for analyzing the sensed response field potentials to predict the likelihood of occurrence of a neurological disorder. - View Dependent Claims (70, 71, 72, 73, 74, 75, 76)
means for measuring a field potential evoked by the first stimulus and the field potential evoked by the second stimulus at the first and second location; and
means for determining a level of functional interconnectivity from a ratio of the response field potentials measured at the first and second locations.
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73. The system of claim 72, wherein the means for analyzing the sensed response field potentials includes means for indicating a likely epileptic event when the level of functional interconnectivity exceeds a predetermined threshold value.
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74. The system of claim 72, wherein the means for analyzing the sensed response field potentials includes means for indicating a likely epileptic event when the level of functional interconnectivity has a negative slope.
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75. The system of claim 71, including means for delivering a therapy for the neurological disorder when the change in the response field potentials exceeds a threshold value.
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76. The system of claim 69, wherein the means for analyzing the sensed response field potentials includes means for analyzing the sensed response field potentials pulses to predict the likelihood of occurrence of an epileptic seizure.
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77. A system comprising:
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means for implanting one or more electrodes in a structure of a brain;
means for delivering electrical stimuli to the structure through the electrodes;
means for sensing response field potentials evoked by the stimuli delivered to the structure;
means for processing the response field potentials to predict the likelihood of occurrence of a neurological disorder based on the sensed response field potentials. - View Dependent Claims (78, 79, 80, 81, 82, 83, 84, 85)
means for measuring a field potential evoked by the first stimulus and the field potential evoked by the second stimulus at the first and second location; and
means for determining a level of functional interconnectivity from a ratio of the response field potentials measured at the first and second locations.
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82. The system of claim 81, wherein the means for processing the response field potentials includes means for indicating a likely epileptic event when the level of functional interconnectivity exceeds a predetermined threshold value.
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83. The system of claim 81, wherein the means for processing the response field potentials includes means for indicating a likely epileptic event when the level of functional interconnectivity has a negative slope.
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84. The system of claim 80, including means for delivering a therapy for the neurological disorder when the change in the response field potential exceeds a threshold value.
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85. The system of claim 77, wherein the means for processing the response field potentials includes means for identifying the occurrence of an epileptic seizure based on the sensed response field potentials.
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86. A system comprising:
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one or more electrode means implantable in a structure of a brain;
a signal processor/generator means coupled to the electrode means, wherein the signal generator means includes;
an electrical pulse generator means to deliver electrical stimuli to the brain via the electrode means implanted in the structure of the brain; and
a signal analyzer means to receive via the electrode means response field potentials to the electrical stimuli delivered with the electrical pulse generator means, where the signal analyzer means receives response field potentials through the electrode means and predicts the likelihood of the occurrence of a neurological disorder based on the sensed response field potentials. - View Dependent Claims (87, 88, 89, 90, 91, 92, 93, 94, 95)
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Specification