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Liposome having an exchangeable component

  • US 6,673,364 B1
  • Filed: 06/12/1998
  • Issued: 01/06/2004
  • Est. Priority Date: 06/07/1995
  • Status: Expired due to Fees
First Claim
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1. A method for increasing the rate of exchange of a bilayer stabilizing component from a liposome formulation to improve multiple dosing, said method comprising:

  • (a) producing a first liposome composition having a lipid, a bioactive agent and a first bilayer stabilizing component, wherein said first bilayer stabilizing component is DSPE-PEG2000;

    (b) determining the rate of exchange of DSPE-PEG2000 from said first liposome composition using a fluorescent lipid mixing assay; and

    (c) preparing a second liposome formulation nearly identical to said first liposome formulation having said lipid, said bioactive agent, but substituting DSPE-PEG2000 from said first liposome composition with a second bilayer stabilizing component having a faster rate of exchanges wherein said second liposome composition results in improved dosing.

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