MRI-guided interventional mammary procedures

• US 6,675,037 B1
• Filed: 09/29/1999
• Issued: 01/06/2004
• Est. Priority Date: 09/29/1999
• Status: Expired due to Fees

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Tsekos, Nikolaos V.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US09/407,346
• Time in Patent Office: 1,560 Days
• Field of Search: 600/407, 600/431, 600/424, 600/415, 600/417, 600/419, 600/420, 600/421, 600/458, 600/461, 378/37, 606/130
• US Class Current: 600/417
• CPC Class Codes: A61B 10/0041 Detection of breast cancer mammography by transillumination A61B5/0091, by X-rays A61B6/502, by ultrasonic means A61B8/0825
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/3958 emitting a signal
• CPC Class Codes: A61B 34/70 Manipulators specially adapted for use in surgery
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/708 Breast positioning means
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61B 90/17 for soft tissue, e.g. breast-holding devices

Abstract

The combination of contrast enhanced magnetic resonance imaging (MRI) and MR-guided subcutaneous core biopsy can be used as a robust approach for the diagnosis and treatment of breast cancer. MRI provides the means to accurately position and monitor interventional procedures such as biopsy, removal of tissue or other transcanular procedures. MRI may also be used in this invention to position and monitor the progress of breast conserving therapies (BCT), such as laser photo-ablation, cryoablation and localized hyperthermia. The general practice of this invention is to provide a remotely controlled apparatus for MR-guided interventional procedures in the breast. The apparatus allows the practice of a method that provides flexibility in conditioning the breast, i.e. orientation and degree of compression, and in setting the trajectory of the intervention. To that end, a robust conditioning/positioning device, fitted with the appropriate degrees of freedom, enhances the efficacy and efficiency of breast interventions by providing the flexibility in planning and executing an appropriate procedure strategy that better suits interventional procedures, either those in current use or yet to be developed. The novelty and potential commercial success of the device originates from its high maneuverability to set and perform the procedure strategy and its adaptability to accommodate an array of interventional probes. Remote control of this device can allow planning the operation and performing the relevant tasks in a short period, for example, within the contrast window provided by a single injection of a contrast agent, and this feature can be operator-independent.

Claims

1. A method for an invasive procedure on a breast of a patient comprising:

positioning a breast of a patient between at least two non-magnetically susceptible supports;

injecting the patient with a contrast agent so that the concentration of the contrast agent within the breast will increase to a maximum concentration for a period of time after injection;

before, during or slightly after the concentration of the contrast agent reaches the maximum concentration, applying pressure to the breast to restrict blood flow within the breast;

maintaining the pressure on the breast to reduce the rate of flow of contrast agent out of the breast; and

examining tissue by a non-invasive procedure of the breast which examining procedure is enhanced by the use of said contrast agent while the rate of blood flow is restricted.

2. The method of claim 1 wherein an invasive procedure on the breast is performed under examination by the non-invasive procedure.

3. The method of claim 2 wherein, after the maximum concentration of contrast agent has occurred and after concentration of the contrast agent has decreased, releasing pressure on said breast, reinjecting the patient with contrast agent, allowing the concentration of contrast agent to increase to a concentration less then the maximum concentration that will occur from the injection, and before the maximum concentration has occurred, applying pressure to the breast to restrict the flow of blood within the breast.

4. The method of claim 3 wherein said non-invasive procedure comprises performing magnetic resonance imaging.

5. The method of claim 2 wherein a device for performing the invasive procedure is supported on a moveable support near one of the at least two non-magnetically susceptible supports, and said device is moved relative to said one of the at least two non-magnetically susceptible supports to position the device for performing invasive surgery on the breast.

6. The method of claim 5 wherein the device is moveable in three dimensions and positioned relative to the at least two non-magnetically susceptible supports.

7. The method of claim 5 wherein said non-invasive procedure comprises performing magnetic resonance imaging.

8. The method of claim 2 wherein said non-invasive procedure comprises performing magnetic resonance imaging.

9. The method of claim 1 wherein at least one of said supports has a window or holes therein and an invasive medical device is inserted through a hole or said window and into the breast.

10. The method of claim 9 wherein said invasive medical device is inserted through said window or hole and into said breast during real-time examining under said non-invasive procedure.

11. The method of claim 9 wherein said non-invasive procedure comprises performing magnetic resonance imaging.

12. The method of claim 1 wherein said non-invasive procedure comprises performing magnetic resonance imaging.