Needle-free injection system

• US 6,676,630 B2
• Filed: 06/04/2002
• Issued: 01/13/2004
• Est. Priority Date: 06/04/2002
• Status: Expired due to Fees

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Medical Technologies Inc. (Inovio Pharmaceuticals, Inc.)
• Inventors: Landau, Sergio, Marshall, John R., Williamson, Dan
• Primary Examiner(s): Hayes, Michael J.
• Application Number:
  US10/164,920
• Publication Number:
  US 20030225368A1
• Time in Patent Office: 588 Days
• Field of Search: 604/68-72
• US Class Current: 604/70
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A needle-free injection device. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Claims

1. A needle-free injection device, comprising:

a syringe assembly configured to draw in and expel injectable fluid, the syringe assembly being configured to expel injectable fluid upon application of pressurized gas to the syringe assembly from a gas reservoir;

a slidable valve assembly configured to control buildup and release of pressure within the gas reservoir, the slidable valve assembly being progressively movable from a priming position to a charging position, and then to a firing position, where;

when in the priming position, the slidable valve assembly fluidly couples the gas reservoir to atmosphere,

when moved from the priming position to the charging position, the slidable valve assembly fluidly couples the gas reservoir with a pressurized gas supply conduit, and

when moved from the charging position to the firing position, the slidable valve assembly causes the gas reservoir to be fluidly coupled with the syringe assembly, enabling pressurized gas from the gas reservoir to act upon the syringe assembly.

2. The needle-free injection device of claim 1, further comprising a pressure-activated valve coupled between the gas reservoir and syringe assembly.

3. The needle-free injection device of claim 2, where when the slidable valve assembly is in the priming position, the slidable valve assembly fluidly couples the pressure-activated valve to the pressurized gas supply conduit, such that the pressure-activated valve closes to seal off the gas reservoir from the syringe assembly upon delivery of pressurized gas through the pressurized gas supply conduit.

4. The needle-free injection device of claim 3, where when the slidable valve assembly is in the firing position, the slidable valve assembly fluidly couples the pressure-activated valve to atmosphere.

5. The needle-free injection device of claim 1, further comprising a spring configured to bias the slidable valve assembly into the priming position.

6. The needle-free injection device of claim 1, further comprising a housing, where the slidable valve assembly includes a valve body fixedly mounted within the housing, and where the slidable valve assembly also includes a sliding structure slidably supported within the valve body, and where relative fore-and-aft movement of the sliding structure and valve body defines the priming, charging and firing positions of the slidable valve assembly.

7. The needle-free injection device of claim 6, where the syringe assembly is fixedly connected to the sliding structure of the slidable valve assembly.

8. The needle-free injection device of claim 7, where syringe assembly includes a nozzle end that extends away from the housing, such that the needle-free injection device is configured to allow a user to grasp the housing and press the nozzle end onto an injection site so as to cause the slidable valve assembly to progressively move from the priming position to the firing position.

9. The needle-free injection device of claim 8, where the needle-free injection device includes a spring configured to return the slidable valve assembly to the priming position upon withdrawal of the needle-free injection device from the injection site.

10. The needle-free injection device of claim 1, further comprising a locking mechanism configured to prevent the slidable valve assembly from moving from the priming position toward the firing position.

11. The needle-free injection device of claim 10, further comprising a user-actuable trigger configured to unlock the locking mechanism.

12. The needle-free injection device of claim 11, where the user-actuable trigger is further configured to open a supply valve and thereby permit delivery of pressurized gas through the pressurized gas supply conduit.

13. The needle-free injection device of claim 1, where the syringe assembly includes a plunger movably disposed within a fluid cylinder.

14. The needle-free injection device of claim 13, further comprising a piston movably disposed within a piston cylinder, where the piston is secured to an end of the plunger, such that advancing the piston causes the plunger to advance within the fluid cylinder and thereby expel fluid from the fluid cylinder.

15. The needle-free injection device of claim 13, where the syringe assembly includes an adjustment mechanism configured to adjust how far the plunger can be retracted from an end of the fluid cylinder, to thereby adjust a maximum volume of injectable fluid that can be expelled from the syringe assembly with a single injection.

16. The needle-free injection device of claim 15, where the syringe assembly includes indicia adapted to provide quantitative indication of the maximum volume of injectable fluid.

17. The needle-free injection device of claim 1, further comprising a fitting assembly configured to couple a fluid supply to an inlet of the syringe assembly, where the inlet includes a check valve to prevent backflow through the fitting assembly.

18. The needle-free injection device of claim 1, further comprising a marking device adapted to place a mark on or near an injection site to indicate an injection has occurred.

19. The needle-free injection device of claim 18, where the marking device is pressure-activated, and where the marking device is fluidly coupled with the needle-free injection device, such that the marking device is activated upon post-injection venting of the needle-free injection device.