Imaging agents for diagnosis of Parkinson's disease
First Claim
Patent Images
1. A compound represented by I:
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whereinX represents O or (H)2;
R represents H, alkyl, alkoxyl, alkylamino, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, alkoxycarbonyl, or alkylaminocarbonyl;
R1 represents —
C(O)OR;
R2 represents H;
R3 represents optionally substituted aryl or heteroaryl;
R4 represents H;
R5 represents independently for each occurrence H, alkyl, alkoxyl, alkylamino, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, alkoxycarbonyl, or alkylaminocarbonyl; and
n is 1,2,3,4, or 5.
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Abstract
Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson'"'"'s disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.
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Citations
14 Claims
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1. A compound represented by I:
-
wherein X represents O or (H)2;
R represents H, alkyl, alkoxyl, alkylamino, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, alkoxycarbonyl, or alkylaminocarbonyl;
R1 represents —
C(O)OR;
R2 represents H;
R3 represents optionally substituted aryl or heteroaryl;
R4 represents H;
R5 represents independently for each occurrence H, alkyl, alkoxyl, alkylamino, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, alkoxycarbonyl, or alkylaminocarbonyl; and
n is 1,2,3,4, or 5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification