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Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device

  • US 6,678,548 B1
  • Filed: 10/20/2000
  • Issued: 01/13/2004
  • Est. Priority Date: 10/20/2000
  • Status: Expired due to Term
First Claim
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1. A method for automatically predicting and preventing the electrographic onset of a seizure in an individual, comprising the acts of:

  • monitoring a plurality of signals indicative of the activity of the brain of the individual;

    extracting a set of features from the signals and forming an optimal feature vector;

    synthesizing a probability vector based on the optimal feature vector as an estimator of the likelihood of seizure for a plurality of prediction time intervals; and

    preventing the electrographic onset of a seizure by the automatic application of at least one intervention measure that is commensurate with the likelihood of seizure.

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