Electrotransport delivery system comprising internal sensors
First Claim
1. A system for the delivery of an active agent through the body surface of a mammal comprising:
- (i) a current supply unit;
(ii) a first apparatus where said first apparatus comprises;
(a) first housing with a first delivery orifice;
(b) a first reservoir within said first housing for containing said first active agent where said first reservoir is in communication with said first delivery orifice;
(c) a first electrode within said first reservoir where said first electrode is in electronic communication with said current supply unit; and
(d) a first sensor within said first reservoir where said first sensor is in electronic communication with said current supply unit;
(iii) a second apparatus where said second apparatus comprises;
(a) a second housing with a second delivery orifice;
(b) a second reservoir within said second housing for containing said second active agent where said second reservoir is in communication with said second delivery orifice;
(c) a second electrode within said second reservoir where said second electrode is in electronic communication with said current supply unit; and
(d) a second sensor within said second reservoir where said second sensor is in electronic communication with said current supply unit; and
wherein said current supply unit reverses the polarity of said first electrode based upon feedback from said first sensor and reverses the polarity of the second electrode based upon feedback from said second sensor.
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Accused Products
Abstract
The present invention relates to an apparatus for the delivery of an active agent through a body surface of a mammal comprising: (a) a housing with a delivery orifice through the housing; (b) a reservoir within the housing for containing the active where the reservoir is in communication with the delivery orifice; (c) an electrode within the reservoir where the electrode is capable of being in electronic communication with a current supply unit; and (d) a sensor within the reservoir where the sensor is capable of being in electronic communication with the current supply unit; wherein the current supply unit can modify an electric parameter at the electrode based upon feedback from the sensor.
279 Citations
22 Claims
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1. A system for the delivery of an active agent through the body surface of a mammal comprising:
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(i) a current supply unit;
(ii) a first apparatus where said first apparatus comprises;
(a) first housing with a first delivery orifice;
(b) a first reservoir within said first housing for containing said first active agent where said first reservoir is in communication with said first delivery orifice;
(c) a first electrode within said first reservoir where said first electrode is in electronic communication with said current supply unit; and
(d) a first sensor within said first reservoir where said first sensor is in electronic communication with said current supply unit;
(iii) a second apparatus where said second apparatus comprises;
(a) a second housing with a second delivery orifice;
(b) a second reservoir within said second housing for containing said second active agent where said second reservoir is in communication with said second delivery orifice;
(c) a second electrode within said second reservoir where said second electrode is in electronic communication with said current supply unit; and
(d) a second sensor within said second reservoir where said second sensor is in electronic communication with said current supply unit; and
wherein said current supply unit reverses the polarity of said first electrode based upon feedback from said first sensor and reverses the polarity of the second electrode based upon feedback from said second sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
(a) affixing said first orifice of said system of claim 2 to the body surface of said mammal;
(b) affixing said second orifice of said system of claim 2 to the body surface of said mammal; and
(c) affixing said third electrode of said system of claim 2 to the body surface of said mammal such that current passes from said third electrode to said first electrode and to the second electrode through the body of said mammal;
wherein said current supply unit supplies current to said first electrode and said second electrode, said current supply unit reverses the polarity of said first electrode based upon the feedback from said first sensor, and said current supply unit reverses the polarity of said second electrode based upon the feedback from said second sensor.
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5. A method of claim 4, wherein said body surface is the skin of said mammal.
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6. A method of claim 4, wherein said first active agent and said second active agent are the same active agent.
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7. A system of claim 1, wherein said first sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said first active agent, ions, and biological compounds.
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8. A system of claim 7, wherein said second sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said second active agent, ions, and biological compounds.
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9. A system of claim 1, wherein said second sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said second active agent, ions, and biological compounds.
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10. A system of claim 1, wherein said current supply unit modifies another electric parameter at said first electrode based upon feedback from said first sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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11. A system of claim 10, wherein said current supply unit modifies another electric parameter at said second electrode based upon feedback from said second sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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12. A system of claim 1, wherein said current supply unit modifies another electric parameter at said second electrode based upon feedback from said second sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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13. A method of claim 1, wherein said first active agent and said second active agent are the same active agent.
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14. A method for delivering an active agent through a body surface of a mammal, said method comprising the steps of:
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(a) affixing said first orifice of said system of claim 1 to the body surface of said mammal; and
(b) affixing said second orifice of said system of claim 1 to the body surface of said mammal such that current passes from said first electrode to the second electrode through the body of said mammal;
wherein said current supply unit supplies current to said first electrode and said second electrode, said current supply unit reverses the polarity of said first electrode based upon the feedback from said first sensor, and said current supply unit reverses the polarity of said second electrode based upon the feedback from said second sensor.
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15. A method of claim 14, wherein said body surface is the skin of said mammal.
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16. A system of claim 14, wherein said first sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said first active agent, ions, and biological compounds.
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17. A system of claim 16, wherein said second sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said second active agent, ions, and biological compounds.
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18. A system of claim 14, wherein said second sensor is selected from the group consisting of sensors for the measurement of pH, conductivity, impedance, said second active agent, ions, and biological compounds.
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19. A system of claim 14, wherein said current supply unit modifies another electric parameter at said first electrode based upon feedback from said first sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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20. A system of claim 19, wherein said current supply unit modifies another electric parameter at said second electrode based upon feedback from said second sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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21. A system of claim 14, wherein said current supply unit modifies another electric parameter at said second electrode based upon feedback from said second sensor where said electric parameter is selected from the group consisting of current intensity and current waveforms.
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22. A method of claim 14, wherein said first active agent and said second active agent are the same active agent.
Specification