Treatments and markers for cancers of the central nervous system

• US 6,680,172 B1
• Filed: 05/16/2000
• Issued: 01/20/2004
• Est. Priority Date: 05/16/2000
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Rickman, David, Kish, Phillip, Zhu, Xiao-Xiang, Tyagi, Rachana, Hanash, Samir M.
• Primary Examiner(s): LACOURCIERE, KAREN A
• Application Number:
  US09/571,479
• Time in Patent Office: 1,344 Days
• Field of Search: 435/7.1, 435/6, 536/23.1
• US Class Current: 435/7.1
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: G01N 33/57407 Specifically defined cancers

Abstract

The present invention relates to novel cancer markers and compositions and methods for cancer therapies. For example, the present invention provides compositions and methods for the detection of gene expression of particular marker genes as indicative of cancers, while control of said gene expression provides for intervention in cancer therapies and, in particular, glioma therapies.

Claims

1. A method for detecting high grade glioma in a subject suspected of having high grade glioma comprising detecting the presence of a TAX-1 protein or polypeptide encoded by the nucleic acid of SEQ ID NO:

5 in a glioma sample from said subject;

thereby detecting high grade glioma in said subject.

2. The method of claim 1, wherein said subject comprises a human subject.

3. The method of claim 1, wherein said detecting the presence of TAX-1 comprises detecting a TAX-1 protein encoded by SEQ ID NO:

5.

4. The method of claim 3, wherein said detecting TAX-1 protein comprises exposing said TAX-1 protein to a TAX-1 specific antibody and detecting the presence of said antibody.

5. The method of claim 1, wherein said detecting the presence of TAX-1 comprises comparing the amount of TAX-1 protein encoded by SEQ ID NO:

5 in said sample to an amount of TAX-1 protein present in a control sample.

6. A method for detecting high grade glioma in a subject suspected of having high grade glioma comprising exposing a glioma sample from said subject to a TAX-1 specific antibody, wherein the binding of said antibody to a TAX-1 protein encoded by the nucleic acid of SEQ ID NO:

5 in said glioma sample is indicative of said subject having high grade glioma.

7. The method of claim 6, wherein said sample comprises a biopsy sample.

8. The method of claim 7, wherein said biopsy sample comprises a brain tissue biopsy.

9. The method of claim 6, wherein said high grade glioma is glioblastoma multiform.