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Engraftable human neural stem cells

  • US 6,680,198 B1
  • Filed: 09/20/1999
  • Issued: 01/20/2004
  • Est. Priority Date: 08/14/1998
  • Status: Expired due to Term
First Claim
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1. A primordial human neural stem cell clone comprising both EGF and bFGF receptors maintained as a stable and identifiable cell line in vitro and suitable for on-demand implantation in vivo into a living host subject, said primordial human neural stem cell clone comprising a pluripotent and self-renewing neural stem cell of human origin, whichi) carries native human genomic DNA, which has not been genetically modified by human intervention means;

  • ii) remains uncommitted and undifferentiated while passaged in vitro using epigenetic means as a mitotic cell line;

    iii) is capable of migrating in vivo after implantation from the implantation site to another anatomic site for in vivo integration within the nervous system of the living host subject;

    iv) is capable of integrating in situ after implantation into the parenchymal tissues at a local anatomic site in the living host subject;

    v) is capable of differentiating in situ into any one of neuronal cell types selected from the group consisting of neurons, oligodendroglia and astroglia as a response to signals in vivo; and

    vi) expresses both EGF and bFGF receptors.

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