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Fourier transform mass spectrometry of complex biological samples

  • US 6,680,203 B2
  • Filed: 12/12/2000
  • Issued: 01/20/2004
  • Est. Priority Date: 07/10/2000
  • Status: Expired due to Fees
First Claim
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1. A method for identifying one or more endogenous molecules that differ in abundance between a first cell population and a second cell population, comprising:

  • (a) comparing a first Fourier Transform Mass Spectrometry (FTMS) peak profile obtained from the first cell population with a second FTMS peak profile obtained from the second cell population;

    (b) identifying one or more peaks that differ in intensity in the first FTMS peak profile relative to the second FTMS peak profile, which one or more peaks correspond to one or more molecules that differ in abundance between a first cell population and a second cell population; and

    (c) identifying said one or more said endogenals molecules that differ in abundance between a first cell population and a second cell population either directly from mass-to-charge (m/z) ratio or through additional fragmentation of said one or more molecules.

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