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3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith

  • US 6,680,303 B2
  • Filed: 05/15/2002
  • Issued: 01/20/2004
  • Est. Priority Date: 01/27/1995
  • Status: Expired due to Fees
First Claim
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1. A β

  • -L or β

    -D nucleoside of the structure;

    embedded imagewherein;

    Y is O;

    Z is O;

    R1 is F;

    R′

    1 is H;

    R2 is independently H, C1 to C6 alkyl, or C(O)(C1 to C6 alkyl); and

    R3 is H, C(O)(C1 to C6 alkyl)2 alkyl, or mono-, di-, or triphosphate or the pharmaceutically acceptable suit thereof.

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