Tissue volume reduction
First Claim
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1. A method of reducing lung volume in a patient, the method comprising:
- (a) advancing a bronchoscope into a region of the lung targeted for reduction; and
(b) introducing biological or biochemical material into the targeted region through the bronchoscope to reduce the volume of the targeted region by inducing collapse of the targeted region;
promoting adhesion between one portion of the collapsed lung and another; and
promoting fibrosis in or around the collapsed region of the lung.
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Abstract
Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
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Citations
32 Claims
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1. A method of reducing lung volume in a patient, the method comprising:
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(a) advancing a bronchoscope into a region of the lung targeted for reduction; and
(b) introducing biological or biochemical material into the targeted region through the bronchoscope to reduce the volume of the targeted region by inducing collapse of the targeted region;
promoting adhesion between one portion of the collapsed lung and another; and
promoting fibrosis in or around the collapsed region of the lung.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for reducing lung volume in a patient, the method comprising
(a) advancing a bronchoscope into a region of the lung targeted for reduction; - and
(b) introducing biological or biochemical material into the targeted region through the bronchoscope to reduce the volume of the targeted region, wherein the biological or biochemical material introduced through the bronchoscope induces collapse of the targeted region; and
promotes adhesion between one collapsed portion of the lung and another.- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A non-surgical method for performing lung volume reduction, the method comprising:
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(a) collapsing a region of the lung;
(b) adhering one portion of the collapsed region to another; and
(c) promoting fibrosis in or around the collapsed region of the lung, wherein promoting fibrosis in or around the collapsed region of the lung is achieved by administering a polypeptide growth factor. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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Specification