Valve for osmotic devices
First Claim
1. An osmotic delivery device for delivery of a beneficial agent, comprising:
- an implantable capsule having a beneficial agent delivery orifice, the beneficial agent delivery orifice positioned between a first end and a second end of the implantable capsule;
a separating member positioned within the capsule between the first and second ends, the separating member dividing said capsule into a beneficial agent reservoir and a driving reservoir;
an osmotic agent positioned in the driving reservoir; and
a valve member positioned with an interior of the capsule between the first end and the beneficial agent reservoir such that the valve member opens and closes the beneficial agent delivery orifice.
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Accused Products
Abstract
An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.
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Citations
39 Claims
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1. An osmotic delivery device for delivery of a beneficial agent, comprising:
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an implantable capsule having a beneficial agent delivery orifice, the beneficial agent delivery orifice positioned between a first end and a second end of the implantable capsule;
a separating member positioned within the capsule between the first and second ends, the separating member dividing said capsule into a beneficial agent reservoir and a driving reservoir;
an osmotic agent positioned in the driving reservoir; and
a valve member positioned with an interior of the capsule between the first end and the beneficial agent reservoir such that the valve member opens and closes the beneficial agent delivery orifice. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An osmotic delivery device, comprising:
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an implantable capsule having first and second ends, the capsule containing an osmotic agent and a beneficial agent; and
a beneficial agent delivery orifice located adjacent to a valve member, wherein the valve member is positioned within an interior of the capsule and movable from a closed position to an open position in response to fluid pressure created by the osmotic agent, in the closed position the valve member blocks fluid flow through the beneficial agent delivery orifice, and in the open position allows passage of fluid through the beneficial agent delivery orifice. - View Dependent Claims (15, 16, 17)
a movable separating member between the osmotic agent and the beneficial agent; and
a permeable membrane retained by the capsule and separating the osmotic agent from a surrounding fluid, wherein in operation, the osmotic agent imbibes the surrounding fluid through the permeable membrane, said osmotic agent forming an osmotic solute which exerts a pressure on the separating member and forces said separating member to move within the capsule, thereby moving the valve member to allow delivery of the beneficial agent through the beneficial agent delivery orifice.
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18. A method of preventing contamination from entering an osmotic delivery device before activation, comprising the steps of:
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providing a delivery device capsule which encloses a first chamber containing a beneficial agent, the first chamber having a beneficial agent delivery orifice communicating with an external environment, and a valve member movable within the capsule; and
positioning the valve member in the delivery device capsule, such that the valve member occludes the beneficial agent delivery orifice. - View Dependent Claims (19, 20)
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21. A method of controlling an initial release of a beneficial agent from an osmotic delivery device, comprising the steps of:
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providing a delivery device capsule which encloses a first chamber containing a beneficial agent, a valve member, and a second chamber containing an osmotic agent, wherein the first chamber has a beneficial agent delivery orifice;
positioning the valve member in the delivery device capsule, wherein before activation the valve member occludes the delivery orifice preventing passage of the beneficial agent contained in the first chamber through the beneficial agent delivery orifice; and
imbibing a surrounding fluid into the osmotic agent to form an osmotic solute which expands and exerts a pressure on the beneficial agent and the valve member, wherein the pressure moves the valve member to a position allowing the beneficial agent contained in the first chamber to pass through the beneficial agent delivery orifice.
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22. An osmotic delivery device for delivery of a beneficial agent, comprising:
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an implantable capsule having a hollow interior and substantially cylindrical side wall and a first end wall and a second end wall, the implantable capsule including;
a cap forming the first end wall of the implantable capsule; and
a capsule body forming the second end wall of the capsule;
a beneficial agent delivery orifice positioned in the cylindrical sidewall between the first and second ends;
a separating member positioned within the capsule between the first and second ends, the separating member dividing said capsule into a beneficial agent reservoir and a driving reservoir;
an osmotic agent positioned in the driving reservoir; and
a valve member positioned within the capsule between the first end and the beneficial agent reservoir such that the valve member occludes the beneficial agent delivery orifice in a first position and allows delivery of a beneficial agent in a second position. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification