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Protease variants and compositions

  • US 6,682,924 B1
  • Filed: 06/05/2000
  • Issued: 01/27/2004
  • Est. Priority Date: 05/05/1995
  • Status: Expired due to Term
First Claim
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1. A modified subtilisin 309 comprising one or both of the following substitutions:

  • (a) Y167A, Y167C, Y167G, Y167H, Y167I, Y167L, Y167M, Y167N, Y167P, Y167Q, Y167S, Y167T, or Y167W, and (b) R170A, R170C, R170F, R170G, R170H, R170I, R170L, R170M, R170N, R170P, R170S, R170T, R170V, or R170W, wherein each position corresponds to a position of the amino acid sequence of subtilisin BPN′

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