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Nucleosides for imaging and treatment applications

  • US 6,683,045 B2
  • Filed: 08/30/2001
  • Issued: 01/27/2004
  • Est. Priority Date: 10/30/1997
  • Status: Expired due to Fees
First Claim
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1. A method for assessing the response of tumors to treatment with a thymidylate synthase inhibitor, comprising the steps of:

  • (a) administering a uridine analogue selected by a method comprising the steps of;

    providing a uridine analogue unsubstituted in the 5-position;

    testing said uridine analog for activation by thymidylate synthase; and

    selecting said uridine analog when found to be activated by thymidylate synthase;

    wherein said uridine analogue is labeled with a positron emitter; and

    (b) determining an extent of maximum thymidylate synthase inhibition and persistence of thymidylate synthase inhibition over time between doses by external imaging.

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