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3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of HIV related diseases

  • US 6,683,079 B2
  • Filed: 07/15/2002
  • Issued: 01/27/2004
  • Est. Priority Date: 04/27/1998
  • Status: Expired due to Fees
First Claim
Patent Images

1. A method of treatment of an HIV infection comprising administration of an effective amount of a compound having the formula (1) embedded imagewherein:

  • Q represents —

    NR1R2 or —

    R0NR1R2 wherein;

    R0 represents C1-5 alkanediyl;

    R1 and R2 are taken together and form a bivalent radical —

    R1-R2

    wherein —

    R1-R2

    represents —

    (CH2)2

    O—

    (CH2)2

    , —

    (CH2)2

    NR7

    (CH2)2, —

    (CH2)2

    CH(NHR7)—

    (CH2)2

    or —

    (CH2)n wherein R7 represents hydrogen or C1-4alkyl and n represents 2, 3, 4, 5 or 6;

    R3 represents phenyl or substituted phenyl;

    R4 and R5 each independently represent hydrogen, C1-6alkyl, C3-6alkenyl, C1-4 alkoxy, C1-4 alkyloxy C1-4 alkyl, amino, mono- or di (C1-4alkyl) amino, formyl, C1-4alkylcarbonyl carboxyl, C1-4alkyloxycarbonyl, or C1-4alkyl aminocarbonyl;

    wherein C1-6alkyl and C3-6alkenyl may be substituted with one, two or three substituents selected from hydroxy, C1-4alkyloxy, C1-4alkyl thio, aryloxy, arylthio, amino, mono- or di(C1-4alkyl)amino and aryl;

    or R4 and R5 taken together form a bivalent radical or formula —

    R4-R5

    wherein —

    R4-R5

    represents —

    CH═

    CH—

    CH═

    CH—

    or —

    (CH2)t, wherein t represents 3 or 4;

    R6 represents hydrogen, hydroxy, C1-4alkyloxy, C1-6alkyl, C3-6alkenyl, aryl, C1-4alkyl, amino, mono- or di(C1-4alkyl)amino or alkylaryl;

    Y represents O or S;

    X represents a radical of formula;

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