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Small organic molecule regulators of cell proliferation

  • US 6,683,192 B2
  • Filed: 09/26/2001
  • Issued: 01/27/2004
  • Est. Priority Date: 03/30/2000
  • Status: Expired due to Term
First Claim
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1. compound represented in general formula (X):

  • embedded imagewherein, as valence and stability permit, Ar represents a substituted or unsubstituted aryl or heteroaryl ring;

    X is selected from —

    C(═

    O)—

    , —

    C(═

    S)—

    , —

    S(O2)—

    , —

    S(O)—

    , and a methylene group optionally substituted with 1-2 lower alkyls;

    Y is absent for each occurrence;

    Z is absent or represents a substituted or unsubstituted aryl, carbocyclyl, heterocyclyl, or heteroaryl ring, or a lower alkyl, nitro, cyano, or halogen substituent;

    R represents, independently for each occurrence, H or substituted or unsubstituted lower alkyl;

    Cy′

    represents a 3-chloro-benzo(b)thien-2-yl, 3-fluoro-benzo(b)thien-2-yl, or 3-methyl-benzo(b)thien-2-yl, wherein the benzo ring is substituted with from 1-4 substituents selected from halogen, nitro, cyano, methyl, and ethyl;

    M represents, independently for each occurrence, a substituted or unsubstituted methylene group, or two M taken together represent substituted or unsubstituted ethene or ethyne, wherein some or all occurrences of M in Mj form all or part of a cyclic structure;

    j represents an integer from 2 to 7;

    i represents 0 for all occurrences except in the sequence N—

    Mi

    Y—

    Ar, where i represents 1;

    and k represents 0.

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