Treatment of disorders by unidirectional nerve stimulation

• US 6,684,105 B2
• Filed: 08/31/2001
• Issued: 01/27/2004
• Est. Priority Date: 08/31/2001
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: BioControl Medical (B.C.M) Ltd.
• Inventors: Cohen, Ehud, Gross, Yossi
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US09/944,913
• Publication Number:
  US 20030045914A1
• Time in Patent Office: 879 Days
• Field of Search: 607/2, 607/40, 607/46, 607/62, 607/63, 607/148, 607/149, 607/45, 600/1-3, 600/9-12, 600/26
• US Class Current: 607/63
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

Apparatus for treating a condition of a subject is provided. An electrode device is adapted to be coupled to longitudinal nervous tissue of the subject, and a control unit is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.

Claims

1. A method for treating a condition of a subject, comprising:

driving into longitudinal nervous tissue of the subject a current which is capable of inducing action potentials that propagate in the nervous tissue in an orthodromic direction, so as to treat the condition; and

suppressing action potentials from propagating in the nervous tissue in an antidromic direction.

2. A method according to claim 1, wherein driving the current comprises driving a current capable of inducing action potentials that propagate in the nervous tissue in an afferent direction with respect to the central nervous system of the subject.

3. A method according to claim 1, wherein driving the current comprises driving a current capable of inducing action potentials that propagate in the nervous tissue in an efferent direction with respect to the central nervous system of the subject.

4. A method according to claim 1, wherein driving the current comprises driving the current into a vagus nerve of the subject.

5. A method according to claim 1, wherein the method comprises driving the current and suppressing the action potentials at substantially the same time.

6. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating an involuntary movement disorder of the subject.

7. A method according to claim 1, wherein suppressing the action potentials comprises regulating the suppressing of the action potentials so as to inhibit an undesired response of the central nervous system of the subject generated responsive to driving the current into the nervous tissue.

8. A method according to claim 1, wherein suppressing the action potentials comprises regulating the suppressing of the action potentials so as to inhibit an undesired sensation generated responsive to driving the current into the nervous tissue.

9. A method according to claim 1, wherein suppressing the action potentials comprises suppressing action potentials induced responsive to driving the current.

10. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating a sleep disorder of the subject.

11. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating a gastrointestinal motility disorder of the subject.

12. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating an eating disorder of the subject.

13. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating obesity of the subject.

14. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating anorexia of the subject.

15. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating a gastrointestinal tract disorder of the subject.

16. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating hypertension of the subject.

17. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating coma of the subject.

18. A method according to claim 1, wherein driving the current comprises configuring the current to be capable of treating epilepsy of the subject.

19. A method according to claim 1, wherein driving the current comprises driving the current into a vagus nerve of the subject and configuring the current to be capable of treating epilepsy of the subject, and wherein suppressing the action potentials comprises suppressing action potentials that interfere with an ability of the subject to speak.

20. A method according to claim 1, wherein driving the current comprises applying to a vagus nerve of the subject a current capable of inducing constriction of a lower esophageal sphincter of the subject.

21. A method according to claim 1, wherein suppressing the action potentials comprises suppressing the action potentials repeatedly, during a series of temporally non-contiguous action potential suppression periods, and wherein the method comprises substantially withholding the suppressing of action potentials between the action potential suppression periods.

22. A method according to claim 1, wherein driving the current comprises driving the current into nervous tissue of the central nervous system of the subject.

23. A method according to claim 1, wherein driving the current comprises driving the current into nervous tissue of the peripheral nervous system of the subject.

24. A method according to claim 1, wherein suppressing the action potentials comprises identifying an action potential conduction velocity and suppressing action potentials characterized by the identified conduction velocity.

25. A method according to claim 24, wherein the method comprises withholding suppression of an action potential having a conduction velocity substantially different from the identified conduction velocity.

26. A method according to claim 1, wherein suppressing the action potentials comprises regulating the suppressing of the action potentials so as to inhibit an undesired effector action responsive to driving the current into the nervous tissue.

27. A method according to claim 26, wherein suppressing the action potentials comprises suppressing generation of action potentials that induce increased acid secretion in a gastrointestinal tract of the subject.

28. A method according to claim 26, wherein suppressing the action potentials comprises suppressing generation of action potentials that induce muscular contraction.

29. A method according to claim 26, wherein suppressing the action potentials comprises suppressing generation of action potentials that induce bradycardia.

30. A method according to claim 1, wherein suppressing the action potentials comprises applying an electric field to the nervous tissue.

31. A method according to claim 30, wherein applying the field comprises applying a plurality of electric fields to the nervous tissue at respective longitudinal sites thereof.

32. A method according to claim 31, wherein applying the plurality of electric fields to the nervous tissue comprises applying each of the fields at a different respective time.

33. A method according to claim 31, wherein applying the fields at the respective longitudinal sites comprises applying the fields at two adjacent sites separated by at least about 2 mm.

34. A method according to claim 31, wherein applying the fields at the respective longitudinal sites comprises applying the fields at two adjacent sites separated by less than about 4 mm.

35. A method according to claim 1, and comprising sensing an indication of a presence of the condition, wherein driving the current comprises driving the current responsive to sensing the indication.

36. A method according to claim 1, and comprising receiving an input from the subject, wherein driving the current comprises driving the current responsive to receiving the input.