Inhaler

• US 6,684,879 B1
• Filed: 08/09/2001
• Issued: 02/03/2004
• Est. Priority Date: 12/17/1998
• Status: Expired due to Fees

• Current Assignee: Battelle Memorial Institute
• Original Assignee: Battelle Memorial Institute
• Inventors: Davies, David Neville, Coffee, Ronald Alan, Pirrie, Alastair Bruce
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): MENDOZA, MICHAEL G
• Application Number:
  US09/868,266
• Time in Patent Office: 908 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.17, 128/203.26, 128/203.27, 128/203.28, 128/200.14, 128/200.16, 604/58
• US Class Current: 128/200.14
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/025 Bubble jet droplet ejection devices
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: B05B 12/00 Arrangements for controlling delivery; Arrangements for controlling the spray area
• CPC Class Codes: B05B 12/004 comprising sensors for monitoring the delivery, e.g. by displaying the sensed value or generating an alarm B05B12/08 takes precedence; registering or indicating the condition or the working of machines or other apparatus in general G07C3/00
• CPC Class Codes: B05B 5/0255 spraying and depositing by electrostatic forces only
• CPC Class Codes: B05B 5/053 Arrangements for supplying power, e.g. charging power
• CPC Class Codes: B05B 5/1691 Apparatus to be carried on or by a person or with a container fixed to the discharge device

Abstract

An inhaler has a housing containing a chamber (1a) providing a reservoir (8) for liquid providing an active ingredient to be supplied to a liquid outlet (10a). First and second electrodes are spaced apart (11 and 12) with the first electrode being spaced apart (11 and 12) with the first electrode being provided at or adjacent the liquid outlet (10a). A voltage supply (5, 7) is activated in response to air flowing through an air inlet (30) of the housing to provide a potential difference between the first and second electrodes (11 and 12) to create an electric field for causing comminution of liquid issuing from the liquid supply outlet (10a) to produce a stream of electrically charged comminuted matter for supply to the nasal passages of a user via an outlet (4) of the housing.

Claims

1. An inhaler, comprising a housing having an outlet and an air inlet, the housing containing:

a liquid supply component comprising;

a chamber providing a reservoir for liquid providing an active ingredient to be supplied to a user and means for supplying liquid from the reservoir to a liquid outlet (liquid supplying means); and

means for creating an electric field (electric field creating means) for causing comminution of liquid issuing from the liquid supplying means outlet in response to air flowing through the air inlet so as to produce a stream of electrically charged comminuted matter for supply to the nasal passages via the housing outlet.

2. An inhaler according to claim 1, wherein the liquid supplying means has first and second outlets;

and the electric field creating means comprises a first electrohydrodynamic comminution means for subjecting liquid issuing from the first outlet to an electrical potential to cause liquid to be comminuted to form a comminution of one polarity; and

a second electrohydrodynamic comminution means for subjecting liquid issuing from the second outlet to an electrical potential to cause the liquid to be comminuted to form a comminution of the opposite polarity, means being provided for providing an air flow to the outlet to modify any mixing of the two opposite polarity comminutions.

3. An inhaler according to claim 1, wherein the electric field creating means comprises first and second spaced apart electrodes with the first electrode being provided at or adjacent the outlet of the liquid supplying means;

and voltage supplying means operable in response to air flowing through the air inlet to provide a potential difference between the first and second electrodes.

4. An inhaler according to claim 3, wherein the voltage supplying means comprises an air flow activated switch for coupling a voltage generating means across the first and second electrodes.

5. An inhaler according to claim 3, wherein the air flow activated switch comprises a closure member and spring biassing means normally biassing the closure member into a position closing off the supply of air into the housing through the air inlet, the closure member being movable against the spring biassing to a position allowing air to flow into the housing through the air inlet in response to the air flow.

6. An inhaler according to claim 1, wherein the housing is arranged to enable a user to create the air flow by breathing in through the housing outlet.

7. An inhaler according to claim 1, further comprising a pump for creating the air flow.

8. An inhaler according to claim 1, wherein the electric field creating means comprises:

first and second spaced apart electrodes with the first electrode being provided at or adjacent the outlet of the liquid supplying means; and

user-operable voltage supplying means for providing a potential difference between the first and second electrodes to create the electric field for causing comminution of liquid issuing from the liquid supplying means outlet to produce a stream of electrically charged comminuted matter, the first and second electrodes being spaced from the housing outlet and being arranged so as to provide, when a potential difference is applied across them by the voltage supplying means, and electric field which reduces rapidly in the direction of liquid flow from the liquid supplying means and the housing having an air flow path to the housing outlet for causing liquid comminuted by the electric field to be entrained by the air flow for supply via the housing outlet to the nasal passages of a user.

9. An inhaler according to claim 3, wherein the first and second spaced apart electrodes are spaced apart in a direction perpendicular to a flow of liquid from the liquid supplying means.

10. An inhaler according to claim 3, wherein the second electrode is located downstream of the liquid outlet.

11. An inhaler according to claim 1, wherein the electric field creating means comprises:

first and second spaced apart electrodes with the first electrode being provided at or adjacent the outlet of the liquid supplying means; and

user-operable voltage supplying means for providing a potential difference between the first and second electrodes to create the electric field for causing comminution of liquid issuing from the liquid supplying means outlet to produce a stream of electrically charged comminuted matter for supply via the housing outlet to the nasal passages of a user, wherein current-limiting means are provided for limiting the supply of current by the voltage supplying means.

12. An inhaler according to claim 11, wherein current-limiting means is coupled to one of the first and second electrodes.

13. An inhaler according to claim 11, wherein the current-limiting means comprises a dielectric or semi-insulating coating or sleeve provided on said one of the first and second electrodes.

14. An inhaler according to claim 8, wherein the voltage supplying means comprises an air flow activated switch for coupling a voltage generating means across the first and second spaced apart electrodes.

15. An inhaler according to claim 14, wherein the air flow activated switch comprises a closure member and spring biassing means normally biassing the closure member into a position closing off the supply of air into the housing through the air inlet, the closure member being movable against the spring biassing to a position allowing air to flow into the housing through the air inlet in response to a user breathing in through the housing outlet or in response to an air supply to the air inlet.

16. An inhaler according to claim 3, wherein the voltage supplying means comprises a further electrode positioned adjacent the second electrode and resistive means coupling the second electrode to earth, the voltage supplying means being arranged to cause the further electrode to generate an ion current for charging the second electrode to an electrical potential sufficient to provide the electrical potential for causing comminution of liquid issuing from the outlet.

17. An inhaler according to claim 1, further comprising:

means for providing a flow of air towards the housing outlet so as to supply the stream of electrically charged comminuted matter to the nasal passages of a user via the housing outlet.

18. An inhaler according to claim 1, further comprising:

means for shearing comminuted matter (shearing means) issuing from the liquid outlet to produce a stream of electrically charged comminuted matter of smaller size than that produced by the electric field for supply to the nasal passages of a user via the housing outlet.

19. An inhaler according to claim 18, wherein the shearing means comprises means for producing airflow in the vicinity of liquid issuing form the liquid outlet.

20. An inhaler according to claim 1, wherein the liquid supplying means comprises means for supplying liquid to first and second outlets;

and the electric field creating means has a first electrohydrodynamic comminution means for subjecting liquid issuing from the first outlet to an electrical potential to cause the liquid to be comminuted to form a comminution of one polarity;

a second electrohydrodynamic comminution means for subjecting liquid issuing from the second outlet to an electrical potential to cause the liquid to be comminuted to form a comminution of the opposite polarity; and

means for providing an air flow to the outlet to modify any mixing of the two opposite polarity comminutions.

21. An inhaler according to claim 2, wherein the air flow providing means is operable to keep the two opposite polarity comminutions apart.

22. An inhaler according to claim 2, further comprising means for controlling at least one of:

1) the relative flow rates of liquid to the first and second liquid outlets;

     2) the relative electrical potentials to which liquid issuing from the first and second outlets is subjected; and

     3) the air flow provided by the air flow providing means.

23. An inhaler according to claim 2, comprising a respective reservoir for each liquid outlet, the reservoirs containing different liquids.

24. An inhaler according to claim 2, wherein the first and second liquid outlets are angled towards one another.

25. An inhaler according to claim 1, further comprising air flow control valve means for controlling the air flowing.

26. An inhaler according to claim 1, further comprising:

means for controlling the size of the components of the comminuted matter.

27. An inhaler according to claim 1, further comprising:

means for controlling the size of the comminuted matter such that the communited matter has at least two different controlled sizes.

28. An inhaler according to claim 1, further comprising means for controlling the diameter of the droplets so that the comminuted matter consists of droplets each having one of at least two different controlled diameters.

29. An inhaler according to claim 22, wherein the controlling means comprises means for superimposing on the voltage supplied by the voltage supplying means an alternating or pulsed signal (superimposing means).

30. An inhaler according to claim 22, wherein the controlling means comprises means for superimposing on the voltage supplied by the voltage supplying means a signal having two different frequency components for causing the comminuted matter to contain two different sizes of components (superimposing means).

31. An inhaler according to claim 29, wherein the superimposing means is arranged to superimpose on the voltage supplied by said voltage supplying means a signal having three or more different frequency components for causing the comminuted matter to contain three or more different sizes of components.

32. An inhaler according to claim 30, wherein said signal is arranged to consist of said frequency components superimposed simultaneously on said voltage in phase with one another.

33. A device according to claim 30, wherein said signal is arranged such that said different frequency components are superimposed one after another on said voltage.

34. An inhaler according to claim 25, wherein the means for controlling the size of the components of the comminution comprises means for regulating the liquid flow and/or the liquid composition.

35. An inhaler according to claim 25, wherein the means for controlling the size of the comminution components comprises a plurality of subsidiary liquid outlets which together form the liquid outlet and respective different cross-section supply pipes for supplying liquid to each different one of the subsidiary liquid outlets.

36. An inhaler according to claim 25, wherein the means for controlling the size of the comminution components comprises a plurality of subsidiary liquid outlets which together form the liquid outlet each having a respective valve means for controlling the liquid flow from the outlet.

37. An inhaler according to claim 1, having a respective housing outlet for each nostril of a user or patient.

38. An inhaler according to claim 1, wherein the air flow is induced other than by inhalation.

39. An inhaler according to claim 1, comprising a biologically acceptable carrier for the active ingredients selected from:

an oil, an alcohol, a polymer or a water-based solvent.

40. An inhaler according to claim 1, comprising a supply of liquid carrying as an active ingredient at least one of the following:

a decongestant, a lipid, a vitamin, an antiseptic, an anti-inflammatory, an antibiotic, an anti-cancer agent, a vaccine, a protein, an enzyme, a bioadhesive, DNA or DNA fragments, nicotine and morphine.

41. A liquid formulation for use in an inhaler in accordance with claim 1, comprising a biologically acceptable carrier liquid for an active ingredient and a polymer.

42. A liquid formulation according to claim 41, wherein the polymer is a medium to high molecular weight polymer.

43. A liquid formulation according to claim 41, wherein the polymer is PVA or PVP.

44. A liquid formulation according to claim 41, wherein the polymer is selected from amongst the following:

0.2 to 0.7 grams per 10 centiliters of formulation of PVA;

0.2 grams per 10 centiliters of formulation of PVA;

from 0.2 to 1.2 grams per 10 centiliters of formulation of PVP;

or 0.5 grams per 10 centiliters of formulation of PVP.

45. A liquid formulation according to claim 41, further comprising as an active ingredient at least one of the following:

a decongestant, a lipid, a vitamin, an antiseptic, an anti-inflammatory, an antibiotic, an anti-cancer agent, a vaccine, a protein, an enzyme, a bioadhesive, DNA or DNA fragments, nicotine and morphine.

46. A delivery device according to claim 1, but differing in that the device is arranged to supply the active ingredient to the mouth, an eye or a bodily orifice and in that air flow is induced other than by inhalation or alternatively by oral inhalation when the device is arranged to supply the active ingredient to or via the mouth.

47. A method of supplying an active ingredient to the nasal passages of a human or animal which comprises using an inhaler in accordance with claim 1.

48. A method of supplying an active ingredient to an eye or bodily orifice other than the mouth or nose which comprises using a delivery device in accordance with claim 46.

49. An inhaler according to claim 26, wherein the components include droplets.

50. A dispensing device comprising a housing having an outlet and an air inlet, the housing containing liquid supplying means comprising:

a chamber providing a reservoir for liquid providing an active ingredient to be supplied to a user and means for supplying liquid from the reservoir to a liquid outlet; and

means for creating an electric field for causing comminution of liquid issuing from the liquid supplying means outlet in response to air flowing through the air inlet so as to produce a stream of electrically charged comminuted matter for supply to the housing outlet, the housing outlet being adapted to supply the comminuted matter containing the active ingredient to at least one of the mouth and eye and a bodily orifice of the user.