Applicator for dispensing bioactive compositions and methods for using the same

• US 6,684,880 B2
• Filed: 12/04/2001
• Issued: 02/03/2004
• Est. Priority Date: 12/04/2001
• Status: Expired due to Term

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Trueba, Kenneth E.
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): Mendoza, Michael G
• Application Number:
  US10/007,133
• Publication Number:
  US 20030101991A1
• Time in Patent Office: 791 Days
• Field of Search: 261/154, 261/130, 261/104, 261/107, 261/DIG.65, 128/203.13, 128/203.15, 128/203.17, 128/203.26, 128/203.27, 128/203.28, 128/200.16, 128/200.14, 604/58
• US Class Current: 128/200.16
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/025 Bubble jet droplet ejection devices
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient

Abstract

An applicator for delivering a bioactive composition includes a jet dispenser having an orifice for ejection of droplets from the dispenser. The jet dispenser further includes a main body. At least partially insertable through the main body is a replaceable fluid reservoir for holding and delivering the bioactive composition to the orifice for ejection therethrough. A body orifice spacer is positioned between the orifice of the dispenser and a target during ejection of the bioactive composition to the target.

Claims

1. An applicator for delivering a bioactive composition, comprising:

an inkjet dispenser comprising an orifice for high-speed ejection of droplets from the dispenser, the inkjet dispenser further comprising a main body;

a replaceable fluid reservoir for holding and delivering the bioactive composition to the orifice for ejection therethrough, the replaceable fluid reservoir at least partially insertable through the body; and

a body orifice spacer positioned between the dispenser orifice and a target during ejection of the bioactive composition to the target;

wherein the dispenser comprises a first orifice and a second orifice, the first orifice operable to dispense droplets of a predetermined size, the second orifice operable to dispense droplets of a predetermined size different than the size of droplets dispensed from the first orifice.

2. The applicator according to claim 1 wherein the applicator is an inhaler.

3. The applicator according to claim 2 wherein the applicator is a pulmonary inhaler.

4. The applicator according to claim 1 wherein the inkjet dispenser is a piezoelectric droplet inkjet dispenser.

5. The applicator according to claim 1 wherein the spacer is external to the body.

6. The applicator according to claim 1 wherein the droplets of the bioactive composition are sized for respiratory inhalation.

7. The applicator according to claim 1 wherein the droplets of the bioactive composition are sized for delivery to bronchial airways.

8. The applicator according to claim 1, further comprising multiple replaceable fluid reservoirs.

9. The applicator according to claim 8 wherein the reservoirs hold and deliver two or more different bioactive compositions.

10. The applicator according to claim 1 wherein the spacer is a mouthpiece spacer or a nasal spacer and the inkjet dispenser is disposed within the spacer.

11. The applicator according to claim 10 further comprising a fluid conduit extending between the fluid reservoir and the inkjet dispenser to deliver bioactive composition from the fluid reservoir to the inkjet dispenser, the fluid conduit extending at least partially through the spacer.

12. The applicator according to claim 1 wherein:

said fluid reservoir comprises a first reservoir and a second reservoir;

said spacer defines an internal pathway;

said inkjet dispenser comprises first and second fluid ejection heads positioned in the internal pathway, each fluid ejection head having a respective orifice through which droplets of the bioactive composition are dispensed; and

the applicator further comprises a first fluid conduit and a second fluid conduit, the first fluid conduit extending between the first fluid reservoir and the first fluid ejection head, the second fluid conduit extending between the second fluid reservoir and the second fluid ejection head.

13. The applicator according to claim 1 wherein the spacer changes a delivery direction.

14. The applicator according to claim 1, further comprising a programmable controller for controlling the inkjet dispenser.

15. The applicator according to claim 14 wherein the programmable controller is a microprocessor operable to dispense a predetermined amount of bioactive composition from the inkjet dispenser.

16. The applicator according to claim 14 wherein the controller is programmable from a remote computer in communication with the controller.

17. The applicator according to claim 14 wherein the controller is programmable from a keypad or touch screen mounted on an external surface of the body and in communication with the controller.

18. An applicator for delivering a bioactive composition comprising:

an inkjet type dispenser comprising plural fluid ejection heads, each ejection head further comprising a dispenser orifice;

multiple containers for holding and delivering the bioactive composition to the orifices, each container operably coupled to each fluid ejection head by an independent conduit; and

a body orifice spacer positioned between the fluid ejection heads and a target during ejection of the bioactive composition to the target;

wherein the multiple containers comprise a first container for holding a first bioactive composition and a second container for holding a second bioactive composition, and the dispenser comprises a first fluid ejection head and a second fluit ejection head, each having at least one dispenser orifice, the first fluid ejection head being configured to dispense droplets of the first bioactive composition having a predetermined size, an the second fluid ejection head being configured to dispense droplets of the second bioactive composition having a predetermined size that is different than the size of the droplets of the first bioactive composition.

19. The applicator according to claim 18 wherein the applicator is an inhaler.

20. The applicator according to claim 18 wherein the dispenser is a piezoelectric droplet jet dispenser.

21. The applicator according to claim 18 wherein the spacer is a mouthpiece spacer or a nasal spacer.

22. The applicator according to claim 18 wherein the spacer is dimensioned for at least partial insertion into a nose or mouth of a human.

23. The applicator according to claim 18 wherein;

the spacer defines a delivery pathway substantially transverse to the applicator and has an open end for positioning at the target;

the dispenser orifices are disposed in the spacer; and

each dispenser orifice is spaced the same distance from the open end of the spacer.

24. The applicator according to claim 18, further comprising a programmable controller for controlling the jet dispenser.

25. The applicator according to claim 24 wherein the programmable controller is a microprocessor.

26. The applicator of claim 24 wherein the controller is programmed to sequentially deliver different bioactive compositions from different containers.

27. The applicator of claim 24 wherein the controller is programmed to simultaneously deliver different bioactive compositions from different containers.

28. The applicator of claim 24 wherein the controller is programmed to deliver bioactive compositions from the applicator in response to clinical or physical information.

29. An applicator for delivering a bioactive composition to a mucous membrane, comprising:

a main body;

a jet dispenser comprising first and second orifices through which droplets of a bioactive composition of a predetermined size are ejected, the size of droplets ejected from the first orifice being different than the size of droplets ejected from the second orifice;

a container for holding and delivering the bioactive composition to the orifices for ejection theretbrough; and

a spacer positioned between the dispenser orifice and the mucous membrane during ejection of the bioactive composition to the mucous membrane, wherein the spacer extends substantially transverse to the body.

30. The applicator according to claim 29 wherein the container is in constant fluid communication with the jet dispenser such that the bioactive composition is allowed to flow from the container to the jet dispenser under the influence of gravity.