Methods for selectively dissolving and removing materials using ultra-high frequency ultrasound

• US 6,685,657 B2
• Filed: 08/31/2001
• Issued: 02/03/2004
• Est. Priority Date: 11/20/1998
• Status: Expired due to Term

• Current Assignee: Joie P. Jones
• Original Assignee: Joie P. Jones
• Inventors: Jones, Joie P.
• Primary Examiner(s): Jaworski, Francis J.
• Assistant Examiner(s): Jung, William C
• Application Number:
  US09/944,829
• Publication Number:
  US 20020000763A1
• Time in Patent Office: 886 Days
• Field of Search: 600/437-472, 601/1-4, 606/169, 604/22
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00547 Prostate

Abstract

The present invention provides processes and apparatus for selectively dissolving and removing unwanted solid and semi-solid materials and the like, within a highly localized region utilizing ultra-high energy acoustical waves having a frequency in the range above 50 MHz, for example from about 50 MHz to about 100 GHz. The invention apparatus includes a piezoelectric transducer that is modified to increase the amplitude of acoustical waves of a given frequency without increase in power to the system. The invention and apparatus have important applications in surgical procedures for the treatment of atherosclerotic plaque, prostate disorders, cancers, orthopedic and cosmetic surgery, various types of orthopedic surgery, including atheroscopic surgery, and the like. The present invention is also useful in a wide variety of non-surgical applications, including industrial processes, wherein materials are desired to be selectively removed in a very localized region.

Claims

1. A method of tissue dissolution comprising:

providing a device comprised of at least one acoustical transducer and least one highly elastic layer having an outer boundary and providing an impedance mismatch interposed between the at least one acoustical transducer and a local region of the tissue;

placing the device so that the at least one highly elastic layer of the at least one transducer is in contact with a surface of the local region of the tissue;

generating by the at least one acoustical transducer, a plurality of acoustical waves comprising at least one series, wherein each acoustical wave is within an ultra-high frequency range; and

applying the at least one series of the generated plurality of acoustical waves, wherein each acoustical wave possesses sufficient amplitude for the at least one series to dissolve the local region of the tissue via the at least one highly elastic layer;

whereby the local region of the tissue is dissolved.

2. The method of tissue dissolution of claim 1 wherein the at least one highly elastic layer is substantially one acoustical wavelength in thickness.

3. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between about 50 megahertz and about 150 megahertz.

4. The method of tissue dissolution of claim 1 further comprising the step of rubbing the at least one highly elastic layer of the device across the surface of the local region of the tissue.

5. The method of tissue dissolution of claim 1, wherein the providing of the device further comprises placing the device within a catheter prior to applying the acoustical waves.

6. The method of tissue dissolution of claim 1, wherein the generated acoustical waves comprise a substantial transverse component.

7. The method of tissue dissolution of claim 1, wherein the generated acoustical waves comprise a substantial transverse component and a longitudinal component.

8. The method of tissue dissolution of claim 1, wherein the generated acoustical waves comprise shear waves propagating from the outer boundary of the at least one highly elastic layer.

9. The method of tissue dissolution of claim 1, wherein the plurality of applied acoustical waves comprise a plurality of acoustical waves of constrained amplitudes wherein each of the plurality of acoustical waves has acoustical energy and wherein the acoustical energy of each wave comprising the plurality of acoustical waves of constrained amplitudes is below a cavitation threshold in water.

10. The method of tissue dissolution of claim 1 wherein the frequency of the plurality of acoustical waves is at least 50 megahertz.

11. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between 50 megahertz and 120 megahertz.

12. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between 50 megahertz and 150 megahertz.

13. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between 50 megahertz and 200 megahertz.

14. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between 200 megahertz and 1 gigahertz.

15. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between 1 gigahertz and 100 gigahertz.

16. The method of tissue dissolution of claim 1 wherein the frequency range of the plurality of acoustical waves is between about 100 gigahertz and about 1 terahertz.

17. A method of tissue dissolution comprising:

providing a device comprised of at least one acoustical transducer and least one highly elastic layer having an outer boundary and providing an impedance mismatch interposed between the at least one acoustical transducer and a local region of the tissue;

placing the device so that the at least one highly elastic layer of the at least one transducer is in contact with a surface of the local region of the tissue;

generating by the at least one acoustical transducer, a plurality of acoustical waves comprising at least one series, wherein each acoustical wave is within an ultra-high frequency range; and

applying the at least one series of the generated plurality of acoustical waves, wherein each acoustical wave possesses sufficient amplitude for the at least one series to dissolve the local region of the tissue via the at least one highly elastic layer;

wherein the at least one series of the generated plurality of acoustical waves are in durations of ten to 100 cycles divided by the frequency;

whereby the local region of the tissue is dissolved.