Self-removing energy absorbing structure for thermal tissue ablation

• US 6,685,699 B1
• Filed: 04/01/2002
• Issued: 02/03/2004
• Est. Priority Date: 06/09/1999
• Status: Expired due to Term

• Current Assignee: MidCap Funding III, LLC, ​Passport Technologies, Inc.
• Original Assignee: Altea Therapeutics Corporation (Nitto Denko Corporation), Spectro Incorporated (Spectro Scientific, Inc.)
• Inventors: McRae, Stuart, Eppstein, Jonathan A.
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US10/018,015
• Time in Patent Office: 673 Days
• Field of Search: 606/2, 606/3, 606/9, 606/13, 604/20, 604/22
• US Class Current: 606/2
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 18/28 for heating a thermal probe or absorber
• CPC Class Codes: A61B 2010/008 Interstitial fluid
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2018/00452 Skin

Abstract

A device to facilitate ablation of tissue, such as for forming one or more openings in the tissue for transdermal monitoring and/or delivery applications. The device comprises: (a) a support layer having at least one aperture therein, and (b) at least one energy absorbent film layer disposed over the at least one aperture in the support layer for making substantial contact with tissue through the aperture. The at least one energy absorbent film layer is under a tension force and absorbs energy focused thereon to thermally ablate the tissue. After ablation, the layer breaks apart allowing access to the ablated tissue beneath it.

Claims

1. A device to facilitate thermal ablation of tissue, comprising:

(a) a support layer having at least one aperture therein; and

(b) at least one energy absorbent film layer disposed over the at least one aperture in the support layer for making substantial contact with tissue through the aperture, wherein the at least one energy absorbent film layer is under a tension force; and

absorbs energy focused thereon to thermally ablate the tissue.

2. The device of claim 1, further comprising an assay pad disposed proximate the aperture in the support layer.

3. The device of claim 2, wherein the assay pad has at least one aperture aligned with the at least one aperture in the support layer.

4. The device of claim 1, wherein the energy absorbent film layer heats up by absorbing energy focused thereon and conducts heat to the tissue thereby ablating the tissue and causing it to break apart over the aperture.

5. The device of claim 1, and further comprising at least one tension member that holds the at least one energy absorbent film layer under tension over the aperture.

6. The device of claim 5, wherein the at least one tension member is comprised of a member selected from the group consisting of elastic, rubber, metal springs, or plastic springs.

7. The device of claim 1, further comprising a reservoir containing at least one drug or agent for release into the tissue.

8. The device of claim 1, wherein the support layer is comprised of:

polyester, ceramic, polycarbonate (PC), polyvinylchloride (PVC), or mixtures thereof.

9. The device of claim 1, wherein the at least one energy absorbent film layer is comprised of copper pythalocyanine.

10. The device of claim 1, wherein the at least one energy absorbent film layer is anchored at ends thereof directly to the support layer.

11. The device of claim 1, wherein the at least one energy absorbent film layer is flexible so as to make contact with the tissue through the aperture when vacuum is applied over the aperture of the support layer.

12. The device of claim 1, wherein the energy absorbent film layer is responsive to energy from the group consisting of;

electromagnetic energy, optical energy, gamma radiation, and/or beta radiation.

13. A method for forming openings in a tissue comprising the steps of:

(a) positioning a support layer having an aperture therein on a tissue;

(b) positioning an energy absorbent film layer over the aperture to make substantial contact with the tissue through the aperture; and

(c) focusing energy onto the at least one energy absorbent film layer to conduct heat to the tissue thereby ablating the tissue.

14. The method of claim 13, further comprising the step of applying vacuum over the aperture to draw the tissue into substantial physical contact with the energy absorbent film layer.

15. The method of claim 13, wherein the energy absorbent film layer breaks apart to provide access to the tissue via the aperture.

16. The method of claim 13, further comprising the step of positioning an assay pad in fluid communication with the tissue via the aperture.

17. The method of claim 13, further comprising the step of contacting the tissue with at least one drug or agent.

18. The method of claim 13, wherein the step of focusing energy comprises focusing energy selected from the group consisting of electromagnetic energy, optical energy, gamma radiation, or beta radiation.