Local drug delivery injection catheter

• US 6,689,099 B2
• Filed: 02/27/2001
• Issued: 02/10/2004
• Est. Priority Date: 07/13/1999
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Mirzaee, Daryush
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Lam, Ann Y.
• Application Number:
  US09/794,791
• Publication Number:
  US 20010007059A1
• Time in Patent Office: 1,078 Days
• Field of Search: 604/93.01, 604/95.01, 604/95.02, 604/95.03, 604/95.04, 604/96.01, 604/97.01, 604/103.01, 604/103.02, 604/264, 604/102.01, 604/102.02, 604/102.03, 604/104
• US Class Current: 604/107
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0086 the needles having bent tips, i.e. the needle distal tips are angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/0087 Multiple injection needles protruding laterally from the distal tip
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A catheter for injecting medication to a specific point within a patient comprises a drug delivery lumen extending from a proximal end of the catheter to an injection port. The catheter comprises a mechanism for angularly pushing the injection port outwardly away from the body of the catheter into an artery wall so that medication can be injected directly into the artery wall.

Claims

1. A medical device comprising:

a catheter having a proximate section and a distal section;

a first member positioned along the catheter and capable of moving towards and away from the distal section of the catheter, the first member including a first section and a second section, the second section capable of bending with respect to the first section in response to the motion of the first member towards and away from the distal section;

a second member supported at a first end by the distal section of the catheter and extending at a second end from the second section of the first member, the second member capable of bending at the first end with respect to the catheter and at the second end with respect to the first member; and

a delivery element comprising a needle for delivering a therapeutic substance to an inner wall of a vessel, wherein the delivery element has a first position substantially parallel to the longitudinal axis of the distal section of the catheter and is configured to move away from the axis of the catheter to a second position in response to the bending of the first member with respect to the second member.

2. The device of claim 1, wherein the first section of the first member comprises a first tube disposed along the catheter, the tube capable of being moved towards and away from the distal section of the catheter for bending the second section of the first member towards and away from the catheter, and wherein the second section of the first member comprises a second tube in fluid communication with the first tube for delivering a therapeutic substance that is supplied in the first tube.

3. A catheter assembly comprising:

a catheter tube having a proximate section and a distal section;

a substance delivery tube telescopically disposed over the catheter tube, wherein the substance delivery tube can be telescopically moved with respect to the catheter tube; and

a substance delivery element comprising a needle supported by the distal section of the catheter tube and in fluid communication with the substance delivery tube, the needle having a first position substantially parallel to the longitudinal axis of the distal section of the catheter tube, wherein the telescopic movement of the substance delivery tube causes the needle to extend away from the catheter tube to a second position.

4. The catheter assembly of claim 3, wherein the substance element additionally comprises:

a first element having a first end and a second end, the first end being in fluid communication with the substance delivery tube; and

a second element having a first end and a second end, the first end being connected to the second end of the first element and the second end being connected to a distal region of the catheter tube, wherein the second element bends with respect to the first element in response to the telescope movement of substance delivery tube.

5. The catheter assembly of claim 4, wherein the needle extends from the second end of the first element, and wherein the first end of the second element includes a recess for receiving the needle when the first and second elements are in a substantially linear configuration.

6. A catheter for delivering a substance, comprising:

a catheter body having a proximate section and a distal section;

a first arm having a first end and a second end;

a second arm having a first end and a second end, the first end of the second arm tending from the second end of the first arm, wherein the first arm and the second arm are capable of bending from a generally linear configuration relative to each other to an angular configuration at the juncture where the second arm extends from the first arm; and

a needle supported by the distal section of the catheter body and extending out from the second end of the first arm for delivering a substance, wherein the needle has a first position substantially parallel to the longitudinal axis of the distal section of the catheter body and is configured to move away from the axis of the catheter body to a second position in response to the bending of the first arm and the second arm.

7. The catheter of claim 6, wherein the first end of the second arm includes a recess for receiving the needle when the first and second arms are in the generally linear configuration.

8. The catheter of claim 6, wherein the first arm comprises:

a hollow tubular body in fluid communication with the needle for allowing the substance to be delivered to the needle; and

a stiffening element extending at least partially along the hollow tubular body for providing rigidity to the hollow tubular body.

9. The catheter of claim 6, wherein the second end of the second arm is coupled to a distal section of the catheter and is configured to bend towards and away from the catheter in response to the bending of the first arm with respect to the second arm.

10. The catheter of claim 6, additionally including a lumen extending at least partially along the catheter and in fluid communication with the first arm, wherein the lumen is adapted to be moved towards and away from a distal end of the catheter for causing the bending movement of the first arm with respect to the second arm.

11. The catheter of claim 6, wherein the first arm has a first position substantially parallel with the longitudinal axis of the catheter.

12. A medical device comprising:

a catheter having a proximate section and a distal section;

a first member positioned along the catheter and capable of moving towards and away from the distal section of the catheter, the first member including a first section and a second section, the second section capable of bending with respect to the first section in response to the motion of the first member towards and away from the distal section;

a second member supported at a first end by the distal section of the catheter and extending at a second end from the second section of the first member, the second member capable of bending at the first end with respect to the catheter and at the second end with respect to the first member;

a delivery element for delivering a therapeutic substance to an inner wall of a vessel, wherein the delivery element has a first position substantially parallel to the longitudinal axis of the distal section of the catheter and is configured to move away from the axis of the catheter to a second position in response to the bending of the first member with respect to the second member;

wherein the delivery element is contacting or penetrating the inner wall of the vessel at the second position; and

wherein the delivery element has an axis and wherein the axis of the delivery element at the second position is about 45°

from the axis of the catheter.

13. A medical device comprising:

a catheter having a proximate section and a distal section;

a first member positioned along the catheter and capable of moving towards and away from the distal section of the catheter, the first member including a first section and a second section, the second section capable of bending with respect to the first section in response to the motion of the first member towards and away from the distal section;

a second member supported at a first end by the distal section of the catheter and extending at a second end from the second section of the first member, the second member capable of bending at the first end with respect to the catheter and at the second end with respect to the first member;

a delivery element for delivering a therapeutic substance to an inner wall of a vessel, wherein the delivery element has a first position substantially parallel to the longitudinal axis of the distal section of the catheter and is configured to move away from the axis of the catheter to a second position in response to the bending of the first member with respect to the second member; and

wherein the first section of the first member comprises a needle, the needle having a first position substantially parallel to the longitudinal axis of the second section of the first member.

14. A medical device comprising:

a catheter having a proximate section and a distal section;

a first member positioned along the catheter, the first member including a first section and a second section, the first section capable of sliding longitudinally along the catheter towards and away from the distal section of the catheter, and the second section capable of pivoting with respect to the first section at a pivoting point in response to the motion of the first section towards and away from the distal section;

a second member supported at a first end by the distal section of the catheter and extending at a second end from the second section of the first member, the second member capable of pivoting at the first end at a pivoting point with respect to the catheter and at the second end with respect to the first member; and

a needle for delivering a therapeutic substance to an inner wall of a vessel, wherein the needle is configured to penetrate the inner wall of the vessel in response to the pivoting of the first member with respect to the second member.

15. The medical device of claim 14, wherein the first section and the second section of the first member are substantially linear.